Last update: July 15, 2017


Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Glycyrrhizinic acid derivative that is extracted from the root of licorice.
Anti-inflammatory effect when topically applied (skin, mouth, throat and rectum).

At latest update no published data on excretion into breast milk were found.

It locally enhances the activity of hydrocortisone by inactivating a cortisol inhibiting enzyme, which can cause toxicity after systemic administration (see info on Licorice).
It is unknown the level of absorption after dermal and oral rinses or application, with a reported case of systemic toxicity following topical use. Hence, it is not recommended a prolonged use of this product during lactation.
It can cause contact dermatitis.

Avoid applying it on the breast, otherwise, clean it thoroughly before breastfeeding.

See below the information of this related product:


We do not have alternatives for Enoxolone.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Enoxolone is also known as

Enoxolone in other languages or writings:


Enoxolone belongs to this group or family:


Main tradenames from several countries containing Enoxolone in its composition:


Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 471 daltons


  1. Omar HR, Komarova I, El-Ghonemi M, Fathy A, Rashad R, Abdelmalak HD, Yerramadha MR, Ali Y, Helal E, Camporesi EM. Licorice abuse: time to send a warning message. Ther Adv Endocrinol Metab. 2012 Abstract Full text (link to original source)
  2. Navarre-Belhassen C, Cambonie G, Boluda C, Hillaire-Buys D. An unexpected case of primary pulmonary hypertension of the neonate (PPHN). Potential role of topical administration of enoxolone. J Perinat Med. 2002 Abstract
  3. Tanaka S, Otsuki T, Matsumoto Y, Hayakawa R, Sugiura M. Allergic contact dermatitis from enoxolone. Contact Dermatitis. 2001 Abstract
  4. Grassi A, Palermi G, Paradisi M. [Study of tolerance and efficacy of cosmetic preparations with lenitive action in atopic dermatitis in children]. Clin Ter. 2000 Abstract
  5. MacKenzie MA, Hoefnagels WH, Kloppenborg PW. Glycyrrhetinic acid and potentiation of hydrocortisone activity in skin. Lancet. 1990 Abstract

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