Last update: July 10, 2014

Ebastine

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Second generation anti-histaminic and piperidine drug with a slightly sedative effect.

Second generation anti-histaminic medicines are considered to be safe while breastfeeding.

On latest update no relevant data related to breastfeeding was found.

Its high protein-binding capacity makes excretion into breast milk unlikely.

For long-term treatment a better known drug related to breastfeeding should be preferred.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Ebastine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ebastine in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 469 daltons
Protein Binding > 95 %
Tmax 2,6 - 4 hours
T1/2 13,8 - 19 hours

References

  1. Kalpaklioglu F, Baccioglu A. Efficacy and safety of H1-antihistamines: an update. Antiinflamm Antiallergy Agents Med Chem. 2012 Abstract
  2. So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010 May;56(5):427-9. Abstract Full text (link to original source) Full text (in our servers)
  3. Leimgruber A. [Treatment of asthma and rhinitis during pregnancy and breast feeding]. Rev Med Suisse. 2007 Abstract
  4. Solhaug V, Roland PD. [Use of antihistaminics during pregnancy and breast feeding]. Tidsskr Nor Laegeforen. 2004 Abstract
  5. Solhaug V, Roland PD. Bruk av antihistaminer under graviditet og amming \ [Use of antihistaminics during pregnancy and breast feeding]. Tidsskr Nor Laegeforen. 2004 Abstract Full text (link to original source) Full text (in our servers)
  6. Yamaguchi T, Hashizume T, Matsuda M, Sakashita M, Fujii T, Sekine Y, Nakashima M, Uematsu T. Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects. Arzneimittelforschung. 1994 Abstract
  7. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  8. Ghaeli P, Kaufman MB. Oral antihistamines/decongestants and breastfeeding. J Hum Lact. 1993 Abstract

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