Last update: July 21, 2020


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

It is a staphylococcal penicillinase resistant penicillin.
Oral or intravenous administration every 6 hours.

Like most penicillin-type antibiotics (Nau 1987), excretion into breast milk is clinically non-significant (Muysson 2020, Matsuda 1984). No harmful effects are expected nor reported in infants whose mothers were taking it.

Widely used for treatment of Mastitis since it has an effective activity against staphylococci resistant to benzylpenicillin (Amir 2014 y 2011, Spencer 2008, Nordeng 2003, Bodley 2000).

The possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account (Briggs 2017, Ito 1993).


We do not have alternatives for Dicloxacillin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dicloxacillin is also known as

Dicloxacillin in other languages or writings:


Dicloxacillin belongs to this group or family:


Main tradenames from several countries containing Dicloxacillin in its composition:


Variable Value Unit
Oral Bioavail. 35 - 76 %
Molecular weight 470 daltons
Protein Binding 95 - 99 %
Tmax 1 - 1,5 hours
T1/2 0,5 - 1 hours
Theoretical Dose 0,008 - 0,045 mg/Kg/d
Relative Dose 0,03 - 0,5 %
Relat.Ped.Dose 0,02 - 0,1 %


  1. Muysson M, Datta P, Rewers-Felkins K, Baker T, Hale TW. Transfer of Dicloxacillin into Human Milk. Breastfeed Med. 2020 Jul 15. Abstract
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  3. Amir LH. y el Comité de protocolos de la Academy of Breastfeeding Medicine. Protocolo clínico de la ABM n.o 4: Mastitis, modi cado en marzo de 2014. Breastfeed Med. 2014;9(5):239-243. Abstract Full text (link to original source) Full text (in our servers)
  4. Amir LH; Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #4: Mastitis, Revised March 2014. Breastfeed Med. 2014;9(5):239-243. Abstract Full text (link to original source) Full text (in our servers)
  5. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Abstract Full text (link to original source) Full text (in our servers)
  6. Spencer JP. Management of mastitis in breastfeeding women. Am Fam Physician. 2008 Abstract Full text (link to original source) Full text (in our servers)
  7. Nordeng H, Tufte E, Nylander G. [Treatment of mastitis in general practice]. Tidsskr Nor Laegeforen. 2003 Abstract
  8. Bodley V, Powers D. Case management of a breastfeeding mother with persistent oversupply and recurrent breast infections. J Hum Lact. 2000 Abstract
  9. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  10. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987 Abstract
  11. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract

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e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) from Mexico

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM