Last update: Aug. 17, 2019

Dexketoprofen Trometamol

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

S - (+) active enantiomer of ketoprofen with similar structure, pharmacokinetics and anti-inflammatory, anti-allergic and antipyretic properties (Valles 2006, Barbanoj 2001).
Oral administration in three daily doses.
Also used as a gel or cream for topical use.

Since the last update we have not found published data on its excretion in breastmilk. But it is presumed to be similar to that of its enantiomer, ketoprofen, whose excretion in milk is insignificant (Jacqz-Aigrain 2007).

Its high percentage of protein binding and short half-life make it unlikely it will transfer into breastmilk in significant amounts.

Most nonsteroidal anti-inflammatory drugs can increase jaundice, so it is preferable to avoid them during the neonatal period in mothers of infants with jaundice. (Janssen 2000).

Because there is less published information than with other drugs in the same group, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.

The forms of cutaneous application have very low systemic absorption through the skin and are compatible with breastfeeding.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dexketoprofen Trometamol is also known as


Dexketoprofen Trometamol in other languages or writings:

Tradenames

Main tradenames from several countries containing Dexketoprofen Trometamol in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 85 %
Molecular weight 254 daltons
Protein Binding 99 %
VD 0,25 l/Kg
pKa 3,88 -
Tmax 0,25 - 1 hours
T1/2 1,65 hours

References

  1. Menarini. Dexketoprofen (Keral). Drug Summary 2018 Full text (in our servers)
  2. AEMPS. Dexketoprofeno. Ficha técnica. 2013 Full text (in our servers)
  3. Jacqz-Aigrain E, Serreau R, Boissinot C, Popon M, Sobel A, Michel J, Sibony O. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther Drug Monit. 2007 Abstract
  4. Valles J, Artigas R, Crea A, Muller F, Paredes I, Zapata A, Capriati A. Clinical pharmacokinetics of parenteral dexketoprofen trometamol in healthy subjects. Methods Find Exp Clin Pharmacol. 2006 Jun;28 Suppl A:7-12. Abstract
  5. Barbanoj MJ, Antonijoan RM, Gich I. Clinical pharmacokinetics of dexketoprofen. Clin Pharmacokinet. 2001;40(4):245-62. Review. Abstract
  6. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med. 2000 Abstract Full text (link to original source) Full text (in our servers)

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