Last update: Aug. 6, 2017

Daclatasvir

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Usually used alone or in combination with sofosbuvir in the treatment of hepatitis C.

Since the last update we have not found published data on its excretion in breast milk.

Its pharmacokinetic data (high molecular weight and very high percentage of plasma protein binding) make it very unlikely that significant amounts will pass into breast milk, so that, although there is disagreement (Thompson 2016), some authors consider that treatment with Daclatasvir, alone or in combination with sofosbuvir is not contraindicated during breastfeeding (Spera 2016, LactMed 2016).


See below the information of these related products:

Alternatives

We do not have alternatives for Daclatasvir.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Daclatasvir in other languages or writings:

Group

Daclatasvir belongs to this group or family:

Tradenames

Main tradenames from several countries containing Daclatasvir in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 67 %
Molecular weight 739 daltons
Protein Binding 99 %
VD 0,66 l/Kg
Tmax 1 - 2 hours
T1/2 12 - 15 hours

References

  1. EMA. Daclatasvir. Ficha técnica. 2017 Full text (in our servers)
  2. EMA. Daclatasvir. Drug Summary. 2017 Full text (in our servers)
  3. Thompson AJ. Australian recommendations for the management of hepatitis C virus infection: a consensus statement. Med J Aust. 2016 Abstract Full text (link to original source) Full text (in our servers)
  4. Spera AM, Eldin TK, Tosone G, Orlando R. Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women? World J Hepatol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  5. LactMed. Daclatasvir. Full Record Display. 2016 Full text (in our servers)

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