Last update: Sept. 19, 2016

Cyproterone Acetate

High Risk for breastfeeding

Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

Progestogen with antiandrogenic properties that is used for the treatment of conditions with hypersexuality, prostate carcinoma, transsexualism and, together with ethinyl estradiol, for hirsutism, acne and alopecia and hyperandrogenism in women.

It is excreted into breast milk in small quantities (Stoppelli 1980), but their anti-androgenic effects could be clinically significant for the infant when doses of 50 milligrams per day or higher are used.

The small amount (2 mg) contained in contraceptive tablets in which it is combined with ethinyl estradiol would represent a very low risk and would be compatible with breastfeeding.


We do not have alternatives for Cyproterone Acetate.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cyproterone Acetate in other languages or writings:


Main tradenames from several countries containing Cyproterone Acetate in its composition:


Variable Value Unit
Oral Bioavail. 88 %
Molecular weight 417 daltons
Protein Binding 96 %
Tmax 2 - 3 hours
T1/2 43 - 50 hours
M/P ratio 1,1 - 9,3 -
Theoretical Dose 0,01 - 0,07 mg/Kg/d
Relative Dose 1,2 - 8,4 %


  1. Bayer. Diane. Product Monograph. 2014 Full text (in our servers)
  2. AEMPS. Ciproterona-Etinilestradiol. Ficha técnica. 2013 Full text (in our servers)
  3. AEMPS. Ciproterona. Ficha técnica. 2011 Full text (in our servers)
  4. AA Pharma. Cyproterone. Product Monograph. 2010 Full text (in our servers)
  5. Stoppelli I, Rainer E, Hümpel M. Transfer of cyproterone acetate to the milk of lactating women. Contraception. 1980 Abstract

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