Last update: Nov. 4, 2018
Minimal risk for breastfeeding and infant.
An antibacterial aminoglycoside used orally in the treatment of intestinal infestations by protozoa (giardia, amoeba and cryptosporidiosis) and by tapeworms. It is also administered orally to suppress intestinal flora prior to surgical interventions and encephalopathy and hepatic coma.
It is used topically in cutaneous leishmaniasis (Garnier 2002) and intramuscularly in visceral leishmaniasis (Musa 2010).
Since the last update we have not found published data on its excretion in breastmilk.
Its practically zero oral bioavailability (Kip 2018, Bissuel 1994) and cutaneous bioavailability (Ravis 2013) impede transfer to the mother’s plasma and therefore it is unlikely that it will be excreted in breastmilk in amounts that could be significant.
Still injected intramuscularly, its lack of lipid solubility (Kit 2018) and short half-life would greatly hinder excretion in breastmilk.
This same low oral bioavailability hinders transfer to infant plasma from breastmilk, except in premature babies and the immediate neonatal period when there may be increased intestinal permeability.
The possible negativity of cultures in febrile infants whose mothers take antibiotics should be taken into account, as well as the possibility of gastroenteritis due to alteration of the intestinal flora (Ito 1993).
We do not have alternatives for Crestomycin Sulphate since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine from United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM