Last update: Aug. 10, 2017


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Proteolytic enzyme which is derived from the fermentation of Clostridium histolyticum that is capable of hydrolyzing and breaking down the peptide collagen bonds. It is a polypeptide formed by about 1,000 amino acids which is a part of the proteases.
It is used topically on ulcers and burns and is injected locally in case of localized connective tissue contracture (Dupuytren).

At latest update relevant published data on excretion into breast milk were not found.

The small dose and low plasma uptake of most topical dermatological preparations make it unlikely a significant excretion into breastmilk.
Following local injections on Dupuytren treatment, no measurable plasma levels are detected (EMA 2016: 5.2).
Its high molecular weight would hinder any excretion into breastmilk.
Because of its protein nature, when orally taken it will be digested in the infant’s gut which should prevent its absorption and passage to the plasma.

It has been used on the nipple to treat and prevent pain and various nipple problems without conclusive results. The best prevention and treatment of problems on the nipple is an adequate latching-on technique (Kuşcu 2002, Morland-Schultz 2005). Whenever applied to the chest or nipple, it should be cleaned up before the next breast feeding.


We do not have alternatives for Collagenase since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Collagenase is also known as

Collagenase in other languages or writings:


Collagenase belongs to this group or family:


Main tradenames from several countries containing Collagenase in its composition:


Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 113.000 daltons


  1. EMA. Colagenasa (Xiapex). Ficha técnica. 2016 Full text (in our servers)
  2. EMA. Collagenase (Xiapex). Drug Summary. 2016 Full text (in our servers)
  3. Morland-Schultz K, Hill PD. Prevention of and therapies for nipple pain: a systematic review. J Obstet Gynecol Neonatal Nurs. 2005 Jul-Aug;34(4):428-37. Review. Abstract
  4. Kuşcu NK, Koyuncu F, Laçin S. Collagenase treatment of sore nipples. Int J Gynaecol Obstet. 2002 Abstract

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