Last update: March 9, 2021

Celecoxib

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Non-steroidal anti-inflammatory drug (NSAID), that functions as a selective inhibitor of the cyclooxygenase-2 (COX-2) enzyme.
Prescribed for the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
Daily oral administration in one or two doses.

Pharmacokinetic data (large volume of distribution and high percentage of protein binding) can explain the observed negligible or null passage into breastmilk, which is not clinically significant (Ruhlen 2007, Gardiner 2006, Hale 2004, Knoppert 2003).
No problems have been reported in infants of mothers that took these drugs (Hale 2004).
The plasma levels of these infants were undetectable or very low (Hale 2004).

Pediatric use authorized in children 2 years of age and older.

Use of this medication is regarded as safe during breastfeeding by various medical societies and expert consensus (Reece 2017, Noviani 2016, Götestam 2016, Briggs 2015, Matsota 2013, Sachs 2013, Østensen 2007).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Celecoxib in other languages or writings:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 99 %
Molecular weight 381 daltons
Protein Binding 97 %
VD 5,7 l/Kg
pKa 10,7 -
Tmax 3 hours
T1/2 11 hours
M/P ratio 0,3 -
Theoretical Dose 0,01 mg/Kg/d
Relative Dose 0,3 %

References

  1. Reece-Stremtan Sarah, Campos Matilde, Kokajko Lauren, and The Academy of Breastfeeding Medicine. Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2017. Breastfeed Med. 2017 Nov;12(9):500-506. Full text (link to original source) Full text (in our servers)
  2. Götestam Skorpen C, Hoeltzenbein M, Tincani A, Fischer-Betz R, Elefant E, Chambers C, da Silva J, Nelson-Piercy C, Cetin I, Costedoat-Chalumeau N, Dolhain R, Förger F, Khamashta M, Ruiz-Irastorza G, Zink A, Vencovsky J, Cutolo M, Caeyers N, Zumbühl C, Østensen M. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016 May;75(5):795-810. Abstract Full text (link to original source) Full text (in our servers)
  3. Noviani M, Wasserman S, Clowse ME. Breastfeeding in mothers with systemic lupus erythematosus. Lupus. 2016 Aug;25(9):973-9. Abstract
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  6. Matsota P, Nakou M, Kalimeris K, Batistaki C, Pandazi A, Kostopanagiotou G. A single dose of celecoxib 200 mg improves postoperative analgesia provided via patient-controlled epidural technique after caesarean section. Arch Med Sci. 2013 Abstract Full text (link to original source) Full text (in our servers)
  7. FDA. Celcoxib. Drug Summary. 2008 Full text (in our servers)
  8. Østensen M, Motta M. Therapy insight: the use of antirheumatic drugs during nursing. Nat Clin Pract Rheumatol. 2007 Abstract
  9. Ruhlen RL, Chen YC, Rottinghaus GE, Sauter ER. RE: \Transfer of celecoxib into human milk\. J Hum Lact. 2007 Abstract
  10. Ruhlen RL, Chen YC, Rottinghaus GE, Sauter ER. RE: "Transfer of celecoxib into human milk". J Hum Lact. 2007 Abstract
  11. Gardiner SJ, Doogue MP, Zhang M, Begg EJ. Quantification of infant exposure to celecoxib through breast milk. Br J Clin Pharmacol. 2006 Abstract Full text (link to original source) Full text (in our servers)
  12. Hale TW, McDonald R, Boger J. Transfer of celecoxib into human milk. J Hum Lact. 2004 Abstract
  13. Knoppert DC, Stempak D, Baruchel S, Koren G. Celecoxib in human milk: a case report. Pharmacotherapy. 2003 Abstract

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