Last update: Sept. 1, 2021

Ceftriaxone Sodium

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Third generation cephalosporin for parenteral administration, once daily or in two divided doses.

Like most cephalosporins for which data are available, it is excreted in breast milk in clinically non-significant amount ((Bourget 1993, Hirabayashi 1988, Cho 1988, Kafetzis 1983) and no problems have been observed in infants whose mothers were treated with ceftriaxone (Kaplan 2017, Bourget 1993).

Because a low oral bioavailability the absorption from ingested milk to infant’s plasma would be zero or negligible, except in case prematurity and immediate neonatal period, when intestinal absorption may be increased.

It is a medication which is approved for use in infants and neonates.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account (Ito 1993).

Expert authors consider the use of this medication safe during breastfeeding (Hale, Lactmed, Briggs 2015, Rowe 2013, Scott 1996, Fulton 1992, Cho 1988).
American Academy of Pediatrics 2001: Medication usually compatible with breastfeeding.
WHO List of Essential Medicines 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Ceftriaxone Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ceftriaxone Sodium in other languages or writings:

Group

Ceftriaxone Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ceftriaxone Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 555 daltons
Protein Binding 95 %
VD 0,2 l/Kg
pKa 2,7 -
Tmax 1 - 3 hours
T1/2 6 - 9 hours
M/P ratio 0,04 -
Theoretical Dose 0,1 mg/Kg/d
Relative Dose 0,15 - 0,6 %
Ped.Relat.Dose 0,1 - 0,2 %

References

  1. Kaplan YC, Keskin-Arslan E, Acar S, Erol-Coskun H. Teicoplanin Use During Breastfeeding. Breastfeed Med. 2017 Mar;12:124. Abstract
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  4. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Scott A, Forsyth S. Breast feeding and antibiotics. Mod Midwife. 1996 Abstract
  7. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  8. Bourget P, Quinquis-Desmaris V, Fernandez H. Ceftriaxone distribution and protein binding between maternal blood and milk postpartum. Ann Pharmacother. 1993 Abstract
  9. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  10. Cho N, Fukunaga K, Kunii K, Deguchi K. [Bacteriological, pharmacokinetic and clinical studies on the use of ceftriaxone in the perinatal period]. Jpn J Antibiot. 1988 Abstract
  11. Hirabayashi K, Okada E. [Pharmacokinetic and clinical studies on ceftriaxone in the perinatal period]. Jpn J Antibiot. 1988 Abstract
  12. Kafetzis DA, Brater DC, Fanourgakis JE, Voyatzis J, Georgakopoulos P. Ceftriaxone distribution between maternal blood and fetal blood and tissues at parturition and between blood and milk postpartum. Antimicrob Agents Chemother. 1983 Abstract Full text (link to original source) Full text (in our servers)
  13. Hale TW. Hale's Medications & Mothers' Milk. [Internet]. Springer Publishing Company; 1991-. Available from: https://www.halesmeds.com None
  14. LactMed. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ None Full text (link to original source)

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