Last update: Sept. 1, 2021
Minimal risk for breastfeeding and infant.
Third generation cephalosporin for parenteral administration, once daily or in two divided doses.
Like most cephalosporins for which data are available, it is excreted in breast milk in clinically non-significant amount ((Bourget 1993, Hirabayashi 1988, Cho 1988, Kafetzis 1983) and no problems have been observed in infants whose mothers were treated with ceftriaxone (Kaplan 2017, Bourget 1993).
Because a low oral bioavailability the absorption from ingested milk to infant’s plasma would be zero or negligible, except in case prematurity and immediate neonatal period, when intestinal absorption may be increased.
It is a medication which is approved for use in infants and neonates.
Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account (Ito 1993).
Expert authors consider the use of this medication safe during breastfeeding (Hale, Lactmed, Briggs 2015, Rowe 2013, Scott 1996, Fulton 1992, Cho 1988).
American Academy of Pediatrics 2001: Medication usually compatible with breastfeeding.
WHO List of Essential Medicines 2002: compatible with breastfeeding.
We do not have alternatives for Ceftriaxone Sodium since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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