Last update: June 4, 2016


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

At latest update no published data on excretion into breast milk were found.

Excretion into breast milk is highly unlikely due to the low absorption through the skin (1%) or vaginal mucosa (8%) and hence a low presence into the blood.

Whenever used on the nipple apply it after feeding and remove excess of cream before the next meal.

It should be avoided the use on the nipple of creams, gels and other products for local application containing paraffin (mineral oil) to keep the infant off from absorption.


We do not have alternatives for C22H16F2N2 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C22H16F2N2 is Flutrimazole in Molecular formula.

Is written in other languages:


Main tradenames from several countries containing C22H16F2N2 in its composition:


Variable Value Unit
Oral Bioavail. 1 (dermat) %
Molecular weight 346 daltons
Tmax 28 hours
T1/2 37 hours


  1. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  2. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  3. John B, Wood SG, Ramis J, Izquierdo I, Forn J. Absorption and excretion of radioactivity after intravaginal administration of an advanced delivery system of 14C-flutrimazole vaginal cream to postmenopausal women. Arzneimittelforschung. 1998 Abstract
  4. Ramis J, Conte L, Segado X, Forn J, Lauroba J, Calpena A, Escribano E, Domenech J. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997 Abstract
  5. Duchène P, Papalexiou P, Ramis J, Izquierdo I, Houin G. Pharmacokinetic profile of [14C]flutrimazole following single topical application in normal and scarified skin of healthy volunteers. Arzneimittelforschung. 1992 Abstract

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write to us at

e-lactancia is a resource recommended by La Liga de la Leche de Euskadi

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM