Last update: Aug. 28, 2020

C09CA06

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

It is an angiotensin II receptor antagonist with actions similar to those of losartan.
It is indicated in the treatment of hypertension and in heart failure.
Oral administration once or twice a day.

Its pharmacokinetic data (high molecular weight and high percentage of plasma protein binding) explain the negligible passage into milk observed (Coberger 2019).
The plasma levels of infants whose mothers take candesartan were indetectable (Coberger 2019).

Its low oral bioavailability makes difficult the absorption towards the infant's plasma from ingested milk, except in prematures or newborns who may show an increased absorption.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

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Other names

C09CA06 is Candesartan Cilexetil in ATC Code/s.

Is written in other languages:

Group

C09CA06 belongs to this group or family:

Tradenames

Main tradenames from several countries containing C09CA06 in its composition:

List of 21 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 14 - 40 %
Molecular weight 611 daltons
Protein Binding 99 %
VD 0,1 l/Kg
pKa 3,44 -
Tmax 3 - 4 hours
T1/2 9 hours
M/P ratio 0,02 -
Theoretical Dose 0,0001 - 0,00038 mg/Kg/d
Relative Dose 0,07 - 0,1 %

References

  1. Coberger ED, Jensen BP, Dalrymple JM. Transfer of Candesartan Into Human Breast Milk. Obstet Gynecol. 2019 Sep;134(3):481-484. Abstract
  2. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  3. As.Zen. Candesartan. DrugSummary. 2013 Full text (in our servers)
  4. AEMPS. Candesartán. Ficha técnica. 2011 Full text (in our servers)
  5. Tamargo j, Caballero R, Gómez R, Núñez L, Vaquero M y Delpón E. Características farmacológicas de los ARA-II. ¿Son todos iguales?. Rev Esp Cardiol Supl. 2006;6:10C-24C. 2006 Full text (in our servers)

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