Last update: Jan. 24, 2016

Amidotrizoate

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

The X-ray contrast media that contain Amidotryzoic acid, Meglumine and Sodium have a content of Iodine from 47% to 62%.
Amidotryzoate excretion into breast milk is nil (Fitzjohn, 1982) or in clinically non-significant amount (Texier, 1983: <0.1% of maternal dose) and there have been no problems in infants whose mothers were on this medication.

The various Iodinated contrast media for imaging examinations (X-rays, CT scans) are considered compatible with breastfeeding since they are rapidly eliminated with little or no release of iodine, not metabolized and virtually not absorbed when taken by mouth. They are structurally very similar to each other, and some of them have shown no or minimal excretion in the breast milk.

Given a low lipoid solubility of the iodinated contrast media, less than 1% of the dose administered to the mother has been found to in the milk.
Due to their low oral bioavailability, intestinal absorption is less than 1% of the dose that would be swallowed by the infant.
The maximum that is finally got by the baby is less than 0.01% of the maternal dose, which represents less than 1% of the dose administered to an infant who undergoes a radiological contrast examination.

Most Scientific Societies of Radiology have agreed that after a radiological iodinated contrast examination is not necessary a temporary weaning of the baby.

American Academy of Pediatrics classifies it as usually compatible with breastfeeding medication.
WHO List of Essential Medicines 2002 states it is compatible with breastfeeding.

Alternatives

We do not have alternatives for Amidotrizoate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Amidotrizoate is also known as


Amidotrizoate in other languages or writings:

Group

Amidotrizoate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Amidotrizoate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 1% %
Molecular weight 636 - 809 daltons
Protein Binding 9 %
Tmax 0,1 hours
T1/2 0,5 - 2 hours
M/P ratio 0,1 -
Relative Dose 0,03 %

References

  1. ACR-American College of Radiology Committee on Drugs and Contrast Media. ACR Manual on Contrast Media v10.3 2018 Abstract Full text (link to original source) Full text (in our servers)
  2. Cova MA, Stacul F, Quaranta R, Guastalla P, Salvatori G, Banderali G, Fonda C, David V, Gregori M, Zuppa AA, Davanzo R. Radiological contrast media in the breastfeeding woman: a position paper of the Italian Society of Radiology (SIRM), the Italian Society of Paediatrics (SIP), the Italian Society of Neonatology (SIN) and the Task Force on Breastfeeding, Ministry of Health, Italy. Eur Radiol. 2014 Abstract
  3. Quintana Rodríguez I. Uso de contrastes radiológicos en la mujer lactante y en niños.. CbSERAM nº 8/14 – Agosto 2014 Abstract Full text (link to original source) Full text (in our servers)
  4. Tremblay E, Thérasse E, Thomassin-Naggara I, Trop I. Quality initiatives: guidelines for use of medical imaging during pregnancy and lactation. Radiographics. 2012 Abstract Full text (link to original source) Full text (in our servers)
  5. Wang PI, Chong ST, Kielar AZ, Kelly AM, Knoepp UD, Mazza MB, Goodsitt MM. Imaging of pregnant and lactating patients: part 1, evidence-based review and recommendations. AJR Am J Roentgenol. 2012 Abstract Full text (link to original source) Full text (in our servers)
  6. Chen MM, Coakley FV, Kaimal A, Laros RK Jr. Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. Obstet Gynecol. 2008 Abstract
  7. Newman J. Breastfeeding and radiologic procedures. Can Fam Physician. 2007 Abstract Full text (link to original source) Full text (in our servers)
  8. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  9. Webb JA, Thomsen HS, Morcos SK; Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR). The use of iodinated and gadolinium contrast media during pregnancy and lactation. Eur Radiol. 2005 Abstract
  10. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  11. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  12. Nielsen ST, Matheson I, Rasmussen JN, Skinnemoen K, Andrew E, Hafsahl G. Excretion of iohexol and metrizoate in human breast milk. Acta Radiol. 1987 Abstract
  13. Texier F, Roque d'Orbcastel O, Etling N. [Stable iodine level in human milk after pulmonary angiography]. Presse Med. 1983 Abstract
  14. FitzJohn TP, Williams DG, Laker MF, Owen JP. Intravenous urography during lactation. Br J Radiol. 1982 Abstract
  15. Ilett KF, Hackett LP, Paterson JW, McCormick CC. Excretion of metrizamide in milk. Br J Radiol. 1981 Abstract
  16. HOLMDAHL KH. Cholecystography during lactation. Acta radiol. 1956 Abstract

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