Last update: Jan. 24, 2016
Minimal risk for breastfeeding and infant.
The X-ray contrast media that contain Amidotryzoic acid, Meglumine and Sodium have a content of Iodine from 47% to 62%.
Amidotryzoate excretion into breast milk is nil (Fitzjohn, 1982) or in clinically non-significant amount (Texier, 1983: <0.1% of maternal dose) and there have been no problems in infants whose mothers were on this medication.
The various Iodinated contrast media for imaging examinations (X-rays, CT scans) are considered compatible with breastfeeding since they are rapidly eliminated with little or no release of iodine, not metabolized and virtually not absorbed when taken by mouth. They are structurally very similar to each other, and some of them have shown no or minimal excretion in the breast milk.
Given a low lipoid solubility of the iodinated contrast media, less than 1% of the dose administered to the mother has been found to in the milk.
Due to their low oral bioavailability, intestinal absorption is less than 1% of the dose that would be swallowed by the infant.
The maximum that is finally got by the baby is less than 0.01% of the maternal dose, which represents less than 1% of the dose administered to an infant who undergoes a radiological contrast examination.
Most Scientific Societies of Radiology have agreed that after a radiological iodinated contrast examination is not necessary a temporary weaning of the baby.
American Academy of Pediatrics classifies it as usually compatible with breastfeeding medication.
WHO List of Essential Medicines 2002 states it is compatible with breastfeeding.
We do not have alternatives for Amidotrizoate since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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