Last update: May 2, 2019

Albendazole

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

A broad-spectrum anthelmintic and antiprotozoal. Indicated in the treatment of systemic helminthiases: echinococcosis and neurocysticercosis (Taenia solium), as well as in intestinal infestations by pinworms, ascarids and other nematodes.
Oral administration in single or daily doses over three days.
It has been used in children under one year of age (Tianyi 2018, Echazú 2017).

Its low intestinal absorption (Pérez 2009) explains why it is excreted in breastmilk in clinically insignificant amounts (Abdel 2009) and no problems have been reported in infants whose mothers were taking it (Dhonukshe 2005).

Its very low oral bioavailability prevents transfer to infant plasma via breastmilk, except in premature babies and the immediate neonatal period when there may be increased intestinal permeability.

It has very low toxicity (Pérez 2009).

Expert authors and the WHO consider its use during breastfeeding to be probably safe (and even indicated to prevent iron deficiency anemia and maternal malnutrition) (Hale 2017 p34, Mofid 2017, Schaefer 2007 p670, Mahadevan 2006, Allen 2002).
List of essential medicines WHO: compatible with breastfeeding (WHO 2002).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Albendazole in other languages or writings:

Group

Albendazole belongs to this group or family:

Tradenames

Main tradenames from several countries containing Albendazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 5 %
Molecular weight 265 daltons
Protein Binding 70 %
pKa 9,51 -
Tmax 2 - 5 hours
T1/2 8,5 - 12,4 hours
M/P ratio 0,9 -
Theoretical Dose 0,1 mg/Kg/d
Relative Dose < 1,5 %
Relat.Ped.Dose <1,5 %

References

  1. Tianyi FL, Agbor VN, Kadia BM, Dimala CA. An unusual case of extensive truncal cutaneous larva migrans in a Cameroonian baby: a case report. J Med Case Rep. 2018 Sep 20;12(1):270. Abstract
  2. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  3. Mofid LS, Gyorkos TW. The Case for Maternal Postpartum Deworming. PLoS Negl Trop Dis. 2017 Jan 5;11(1):e0005203. Abstract
  4. Echazú A, Juarez M, Vargas PA, Cajal SP, Cimino RO, Heredia V, Caropresi S, Paredes G, Arias LM, Abril M, Gold S, Lammie P, Krolewiecki AJ. Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study. PLoS Negl Trop Dis. 2017 Oct 9;11(10):e0006003. Abstract
  5. GSK. Albendazol (Zentel). Drug summary. 2011 Full text (in our servers)
  6. Abdel-tawab AM, Bradley M, Ghazaly EA, Horton J, el-Setouhy M. Albendazole and its metabolites in the breast milk of lactating women following a single oral dose of albendazole. Br J Clin Pharmacol. 2009 Nov;68(5):737-42. Abstract Full text (link to original source) Full text (in our servers)
  7. Pérez JL, Carranza C, Mateos F. Antiparasitarios. Revisión de los fármacos útiles en el tratamiento de parasitosis clásicas y emergentes. \ [Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases]. Rev Esp Quimioter. 2009 Jun;22(2):93-105. Review. Spanish. Abstract Full text (link to original source) Full text (in our servers)
  8. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007
  9. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  10. Dhonukshe-Rutten RA, Vossenaar M, West CE, Schümann K, Bulux J, Solomons NW. Day-to-day variations in iron, zinc and copper in breast milk of Guatemalan mothers. J Pediatr Gastroenterol Nutr. 2005 Feb;40(2):128-34; discussion 120-1. Abstract
  11. AEMPS - Allen. Albendazol (Eskazole). Ficha técnica. 2004 Full text (in our servers)
  12. Allen HE, Crompton DW, de Silva N, LoVerde PT, Olds GR. New policies for using anthelmintics in high risk groups. Trends Parasitol. 2002 Sep;18(9):381-2. Review. Abstract
  13. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)

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