Last update: Aug. 12, 2014

Acetazolamide

Very Low Risk for breastfeeding


Compatible.
Not risky for breastfeeding or infant.

Carbonic anhydrase inhibitor diuretic that has been used in the treatment of glaucoma, intracraneal hypertension and some types of epilepsy.

Small amonut presented in the breast milk does not have any effect on the nursing baby.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Alternatives

We do not have alternatives for Acetazolamide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Group

Acetazolamide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Acetazolamide in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 95 %
Molecular weight 222 daltons
Protein Binding 90 %
VD 0,2 l/Kg
Tmax 3 hours
T1/2 6 hours
M/P ratio 0,3 -
Theoretical Dose 0,3 mg/Kg/d
Relative Dose 1,8 %
Relat.Ped.Dose 1 - 3 %

References

  1. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  4. Merlob P, Litwin A, Mor N. Possible association between acetazolamide administration during pregnancy and metabolic disorders in the newborn. Eur J Obstet Gynecol Reprod Biol. 1990 Abstract
  5. Söderman P, Hartvig P, Fagerlund C. Acetazolamide excretion into human breast milk. Br J Clin Pharmacol. 1984 Abstract

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