Last update March 3, 2022
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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扎鲁司特 is Zafirlukast in Chinese.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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It is a selective leukotriene receptor antagonist with actions and uses similar to those of montelukast. Used in the management of asthma. Oral administration twice daily.
Pharmacokinetic data (moderately high molecular weight, very high percentage of protein binding, high volume of distribution and low pKa) would explain the negligible excretion in breast milk observed in a single publication provided by the manufacturer. (AstraZeneca 2013)
Its low oral bioavailability, mostly when taken with food, hinder plasma passage from ingested milk by the infant except in preterm and immediate neonatal infants, who may have a greater intestinal absorption.
It has been used in infants from 12 months of age.
A drug of the same group and similar effect, the Montelukast, is excreted into breast milk in negligible amount.
Some authors consider the use of this medication to be probably safe during breastfeeding. (Nice 2004)
Until more data is available regarding breastfeeding, it may be preferable to choose alternatives that are known to be safer, especially in the neonatal period and/or in case of prematurity.
See below the information of this related product: