Last update Nov. 5, 2024

Sodium Cromoglicate, Cromolyn Sodium

Compatible

Safe product and/or breastfeeding is the best option.

It is a chromogenic complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is administered by inhalation for the prevention of asthma and atopic rhinitis, orally in food allergies and topically in dermatology and ophthalmology. 

At the date of last update we found no published data on its excretion in breast milk. 

The small dose and low plasma absorption of most inhaled (buccal or nasal), ophthalmologic or topical dermatologic preparations make the passage of significant amounts into breast milk unlikely. 

Their low oral bioavailability makes it difficult for them to pass into infant plasma from ingested breast milk, except in premature infants and the immediate neonatal period in which there may be greater intestinal permeability.

There is consensus among experts and scientific societies that sodium cromoglycate is compatible with breastfeeding(Hale, LactMed, Brigggs 2015, Nelson 2001, National Asthma Education 2004, Powrie 2006, Nice 2004) due to its minimal absorption and low plasma levels in the mother. (AEMPS 2013, Davis 2015)

WHO 2002 essential drug list: compatible with breastfeeding. (WHO 2002)

Alternatives

We do not have alternatives for Sodium Cromoglicate, Cromolyn Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sodium Cromoglicate, Cromolyn Sodium is also known as


Sodium Cromoglicate, Cromolyn Sodium in other languages or writings:

Tradenames

Main tradenames from several countries containing Sodium Cromoglicate, Cromolyn Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. <1 oral. 7-10 inhal. 0.03 oft. %
Molecular weight 512 daltons
Protein Binding 65 %
pKa 1.61 -
Tmax 0.2 hours
1.3 - 1.5 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Davis C. Cromolyn. Drug Summary. 2015 Full text (in our servers)
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. AEMPS. Cromoglicato. Ficha técnica. 2013 Full text (in our servers)
  6. Powrie RO, Larson L, Miller M. Managing asthma in expectant mothers. Treat Respir Med. 2006;5(1):1-10. Abstract
  7. Nice FJ, De Eugenio D, Dimino TA, Freeny IC, Rovnack MB, Gromelski JS. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and Other Healthcare Professionals. Part I. J Pharm Technol 2004;20:17-27. doi: 10.1177/875512250402000106.
  8. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. None 2004 Full text (link to original source) Full text (in our servers)
  9. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)

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