Last update June 27, 2022

Viloxazine Hydrochloride

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

It is a bicyclic antidepressant. Used in the treatment of depression and attention deficit hyperactivity disorder (ADHD) in adults and children. Oral administration once daily.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data do not allow predicting the possible excretion in breast milk: while its high distribution volume would make it difficult, its low protein binding and low molecular weight would favor it.

May cause drowsiness, fatigue, irritability, and suicidal ideation. (FDA 2021)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Dexamfetamine Sulfate (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Methylphenidate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Paroxetine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Sertraline Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Viloxazine Hydrochloride in other languages or writings:

Groups

Viloxazine Hydrochloride belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Viloxazine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 88 %
Molecular weight 274 daltons
Protein Binding 76 - 82 %
VD 0.73 ± 0.28 l/Kg
Tmax 5 (3 - 9) hours
7.0 ± 4.7 hours

References

  1. FDA. Viloxazine (Qelbree). Frug Summary. 2021 Full text (in our servers)

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