Last update Jan. 6, 2021
Prodrug derived from ganciclovir. It is rapidly converted to ganciclovir through first pass intestinal and hepatic metabolism.
Prescribed for the treatment of Cytomegalovirus (CMV) retinitis in patients with AIDS and for prevention of disease from CMV in organ transplant recipients that have received an organ from a donor that tested positive for CMV.
Administered orally twice a day.
We could not find published data regarding the excretion of this substance through breast milk at the time this last update was completed.
Due to its pharmacokinetic data (Roche 2018, Aurovitas 2015) it is difficult to accurately predict whether excretion through breast milk occurs. While its low molecular weight and negligible protein binding would facilitate it, its high distribution volume would impede it.
It possesses a much superior bioavailability compared to ganciclovir and therefore ganciclovir should be preferred when breastfeeding.
It has been used in infants and newborns (Roche 2018).
Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.
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