Last update Jan. 6, 2021
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Letermovir in other languages or writings:
Main tradenames from several countries containing Letermovir in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 35 (+CP: 85) | % |
Molecular weight | 573 | daltons |
Protein Binding | 99 | % |
VD | 0.65 | l/Kg |
pKa | 3.75 - 7.15 | - |
Tmax | 0.75 - 2.25 | hours |
T½ | 12 | hours |
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e-lactancia is a resource recommended by La Liga de la Leche, España of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Antiviral prescribed for profilaxis from cytomegalovirus (CMV) infeccion in recipients of allogeneic hematopoietic stem cell transplants.
Administered orally or intravenously once a day.
We could not find published data regarding the excretion of this substance through breast milk at the time this last update was completed.
Due to its pharmacokinetic data (large distribution volume, moderately high molecular weight and very high protein binding percentage: EMA 2018), it is very unlikely for any significant amounts to pass into human milk.
When it is not combined with ciclosporin, its low oral bioavailability (35%: EMA 2018) makes it very difficult for this substance to reach a breastfeeding infant´s plasma. There may be greater intestinal permeability in preterm infants and during the immediate neonatal period but even then the amount that could pass into breast milk would still be clinically negligible.
See below the information of this related product: