Last update June 23, 2022

Triphthazinum

Compatible

Safe product and/or breastfeeding is the best option.

Typical, first generation antipsychotic, phenothiazine, with pharmacological action similar to chlorpromazine. Used in the treatment of schizophrenia and other psychoses. It is also useful in the treatment of nausea and vomiting of central origin. Oral administration in 2 daily doses.

It is excreted in breast milk in clinically insignificant amounts. (Yoshida 1998) 

No problems have been observed in infants whose mothers have taken it. (Goldstein 2000, Birnbaum 1999, Yoshida 1998)

Urine levels in one infant were very low. (Yoshida 1998)

Like other phenothiazines, it can cause hyperprolactinemia and produce galactorrhea. (Gruen 1978, Meltzer 1976, Hussain 1972)

Some authors consider it very safe during lactation (Parikh 2014). Until more published data is known about this drug in relation to breastfeeding, known safer alternatives may be preferable (Hale, LactMed, Uguz 2021, Parikh 2014, Klinger 2013), especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

Alternatives

  • Olanzapine (Safe product and/or breastfeeding is the best option.)
  • Perphenazine (Safe product and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Triphthazinum is also known as Trifluoperazine Hydrochloride. Here it is a list of alternative known names::


Triphthazinum in other languages or writings:

Groups

Triphthazinum belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Triphthazinum in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Alta - Hig %
Molecular weight 480 daltons
Protein Binding 90 - 99 %
Tmax 2 - 4 hours
10 - 20 hours
M/P ratio 0 -
Theoretical Dose 0 mg/Kg/d
Relative Dose 0 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract
  4. Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review. Abstract
  5. Goldstein DJ, Corbin LA, Fung MC. Olanzapine-exposed pregnancies and lactation: early experience. J Clin Psychopharmacol. 2000 Aug;20(4):399-403. Abstract
  6. Birnbaum CS, Cohen LS, Bailey JW, Grush LR, Robertson LM, Stowe ZN. Serum concentrations of antidepressants and benzodiazepines in nursing infants: A case series. Pediatrics. 1999 Abstract Full text (link to original source)
  7. Yoshida K, Smith B, Craggs M, Kumar R. Neuroleptic drugs in breast-milk: a study of pharmacokinetics and of possible adverse effects in breast-fed infants. Psychol Med. 1998 Abstract
  8. Gruen PH, Sachar EJ, Langer G, Altman N, Leifer M, Frantz A, Halpern FS. Prolactin responses to neuroleptics in normal and schizophrenic subjects. Arch Gen Psychiatry. 1978 Jan;35(1):108-16. Abstract
  9. Meltzer HY, Fang VS. The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry. 1976 Mar;33(3):279-86. Abstract
  10. Hussain MZ, Harinath M, Murphy J. Tranquillizer-induced galactorrhea. Can Med Assoc J. 1972 May 20;106(10):1107-8. No abstract available. Abstract

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