Last update Jan. 30, 2021
Compatible
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Tiotropium Bromide in other languages or writings:
Main tradenames from several countries containing Tiotropium Bromide in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 2 (inhal: 19) | % |
Molecular weight | 472 | daltons |
Protein Binding | 72 | % |
VD | 32 | l/Kg |
pKa | 10.35 | - |
Tmax | 0.1 | hours |
T½ | 24 - 44 | hours |
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e-lactancia is a resource recommended by La Liga de la Leche, España of Spain
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Long-acting anticholinergic, specific antagonist of muscarinic receptors, which inhibits the bronchoconstrictive effects of acetylcholine.
Indicated in the treatment of asthma.
Inhaled administration.
Since the last update we have not found any published data on its excretion in breast milk.
Because of a very large volume of distribution along with a very low plasma concentration reached after inhalation (AEMPS 2019, Boehringer 2017), it must be very unlikely the passage of significant amounts into breastmilk.
Its almost nil oral bioavailability (AEMPS 2019, Boehringer 2017) would hamper the pass to the infant’s plasma through the breastmilk ingested.
Experts and scientific societies consider the use of inhaled anticholinergics during breastfeeding as low risk to the infant ((Hale, Lactmed, Amir 2011, National Asthma Education 2004).