Last update Nov. 7, 2024

Salmeterol Xinafoate

Compatible

Safe product and/or breastfeeding is the best option.

Long-acting bronchodilator similar in structure to salbutamol. Inhaled twice daily administration.

At the date of last update we did not find published data on its excretion in breast milk.

Its high binding to plasma proteins, very large volume of distribution, moderately high molecular weight and the fact that, after inhalation, it reaches very low or undetectable plasma concentrations (Hale, Cazzola 2002, AEMPS 2012) make it very unlikely that significant quantities will pass into milk.

Terbutaline, a molecule of the same family, is excreted in negligible amounts in breast milk.

Several medical societies and expert authors consider the use of inhaled bronchodilators safe during breastfeeding due to low maternal serum levels (Lactmed, Bendien 2024, Amir 2011, National Asthma 2004, Nelson 2001, Ellsworth 1994).


See below the information of this related product:

Alternatives

We do not have alternatives for Salmeterol Xinafoate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Salmeterol Xinafoate in other languages or writings:

Group

Salmeterol Xinafoate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Salmeterol Xinafoate in its composition:

  • Advair™. Contains other elements than Salmeterol Xinafoate in its composition
  • Aerometrol Plus™. Contains other elements than Salmeterol Xinafoate in its composition
  • Airduo™. Contains other elements than Salmeterol Xinafoate in its composition
  • Airflusal™. Contains other elements than Salmeterol Xinafoate in its composition
  • Aliflus
  • Anasma™. Contains other elements than Salmeterol Xinafoate in its composition
  • Arial
  • Asmabron™. Contains other elements than Salmeterol Xinafoate in its composition
  • Atmadisc™. Contains other elements than Salmeterol Xinafoate in its composition
  • Aurituss™. Contains other elements than Salmeterol Xinafoate in its composition
  • Beglan
  • Betamican
  • Brexotide
  • Brisair
  • Brisomax™. Contains other elements than Salmeterol Xinafoate in its composition
  • Bromex (Chile)™. Contains other elements than Salmeterol Xinafoate in its composition
  • Brulsar
  • Byany
  • Combitide
  • Crivanil Plus
  • Dilamax
  • Duoxten™. Contains other elements than Salmeterol Xinafoate in its composition
  • Esiflo
  • Flixovent™. Contains other elements than Salmeterol Xinafoate in its composition
  • Flunacross-S
  • Flutivent™. Contains other elements than Salmeterol Xinafoate in its composition
  • Fluxamol™. Contains other elements than Salmeterol Xinafoate in its composition
  • Forair
  • Foxair
  • Inaladuo™. Contains other elements than Salmeterol Xinafoate in its composition
  • Inaspir
  • Inhalan Bronquial™. Contains other elements than Salmeterol Xinafoate in its composition
  • Irflosol™. Contains other elements than Salmeterol Xinafoate in its composition
  • Lasfligen™. Contains other elements than Salmeterol Xinafoate in its composition
  • Lirtodac Plus
  • Maizar™. Contains other elements than Salmeterol Xinafoate in its composition
  • Meterol
  • Neumotide™. Contains other elements than Salmeterol Xinafoate in its composition
  • Nimbus™. Contains other elements than Salmeterol Xinafoate in its composition
  • Plusvent™. Contains other elements than Salmeterol Xinafoate in its composition
  • Proair Bronquial™. Contains other elements than Salmeterol Xinafoate in its composition
  • Respiro™. Contains other elements than Salmeterol Xinafoate in its composition
  • Rivilio™. Contains other elements than Salmeterol Xinafoate in its composition
  • Rolenium™. Contains other elements than Salmeterol Xinafoate in its composition
  • Salflutop™. Contains other elements than Salmeterol Xinafoate in its composition
  • Salmeflo
  • Salmetedur
  • Salmeter
  • Sereflo
  • Seretaide
  • Seretide™. Contains other elements than Salmeterol Xinafoate in its composition
  • Serevent
  • Serobid
  • Seroflo
  • Soltel
  • Stalpex
  • Tevacomb
  • Thoreus
  • Ulfhinlas™. Contains other elements than Salmeterol Xinafoate in its composition
  • Ultrabeta
  • Veraspir™. Contains other elements than Salmeterol Xinafoate in its composition
  • Vetalone™. Contains other elements than Salmeterol Xinafoate in its composition
  • Viani™. Contains other elements than Salmeterol Xinafoate in its composition
  • Wixela™. Contains other elements than Salmeterol Xinafoate in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 604 daltons
Protein Binding 96 - 98 %
VD 2.5 - 45.1 l/Kg
pKa 10.12 -
Tmax 0.1 - 0.3 hours
5.5 hours
M/P ratio 1 -

References

  1. Bendien SA, de Kruif MD, Feitsma H, van Hoolwerff-Blikkendaal C, Huurne KK, Kuiterman A, Baranova EV, Wittkamp A, Brons A, Poulissen M, van der Meer AN. Summary of the Dutch Multidisciplinary Practice Guideline on Asthma and Pregnancy. J Allergy Clin Immunol Pract. 2024 Jul;12(7):1751-1762. Consulted on Nov. 7, 2024 Abstract
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Chambers CD, Krishnan JA, Alba L, Albano JD, Bryant AS, Carver M, Cohen LS, Gorodetsky E, Hernandez-Diaz S, Honein MA, Jones BL, Murray RK, Namazy JA, Sahin L, Spong CY, Vasisht KP, Watt K, Wurst KE, Yao L, Schatz M. The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities. J Allergy Clin Immunol. 2021 Jun;147(6):2009-2020. Abstract Full text (link to original source)
  4. PDR.net Fluticasone-Salmeterol Drug Summary 2013 Full text (in our servers)
  5. AEMPS. Salmeterol. Ficha técnica. 2012 Full text (in our servers)
  6. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  7. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. None 2004 Full text (link to original source) Full text (in our servers)
  8. Nice FJ, De Eugenio D, Dimino TA, Freeny IC, Rovnack MB, Gromelski JS. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and Other Healthcare Professionals. Part I. J Pharm Technol 2004;20:17-27. doi: 10.1177/875512250402000106.
  9. Cazzola M, Testi R, Matera MG. Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet. 2002 Abstract
  10. Nelson-Piercy C. Asthma in pregnancy. Thorax. 2001 Abstract Full text (link to original source) Full text (in our servers)
  11. Ellsworth A. Pharmacotherapy of asthma while breastfeeding. J Hum Lact. 1994 Abstract

Total visits

22,941

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by IHAN of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM