Last update April 6, 2025

Thiocolchicoside

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Muscle relaxant marketed in some countries, often in combination with paracetamol.  Oral administration in two daily doses or intramuscular administration.

At the date of last update we found no published data on its excretion in breast milk.

Seizures have been reported in a 3-month-old infant on the third day after the mother took 8 mg of thiocolchicoside. (Havali 2019)

Seizures have been reported in predisposed individuals (Giavina 2009, De Riu 2001). Possible mutagenic effects in prolonged use have been reported.

The European Medicines Agency recommends restricting the use of thiocolchicoside by mouth or injection. (EMA 2014)

Product with very few bibliographic references, not recommended during breastfeeding, especially while breastfeeding is exclusive and the infant is less than 6 months old. To minimise exposure, it is advisable to wait 24 hours after the last dose before resuming breastfeeding.

Alternatives

  • Baclofen (Safe product and/or breastfeeding is the best option.)
  • Diazepam (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Methocarbamol (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Thiocolchicoside in other languages or writings:

Group

Thiocolchicoside belongs to this group or family:

Tradenames

Main tradenames from several countries containing Thiocolchicoside in its composition:

List of 22 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 %
Molecular weight 564 daltons
Protein Binding 13 %
VD 0.4 - 0.6 l/Kg
pKa 12.2 -
Tmax 0.5 - 1 hours
T½ 1.5 - 7 hours

References

  1. Havali C, Gucuyener K, Gurkas E, Demir E. Temporary Seizure in an Infant Who Had Been Exposed to G-Amino Butyric Acid Receptor Antagonist Thiocolchicoside. Pediatr Emerg Care. 2019 May;35(5):e96-e97. Abstract
  2. AEMPS. Tiocolchicosido. Ficha técnica 2015 Full text (in our servers)
  3. EMA. La Agencia Europea de Medicamentos recomienda restringir el uso del tiocolchicósido por vía oral o inyectable. 2014 Full text (in our servers)
  4. EMA. Thiocolchicoside. Drug Summary. 2013 Full text (in our servers)
  5. EMA. European Medicines Agency recommends restricting use of thiocolchicoside by mouth or injection. 2013 Full text (in our servers)
  6. Giavina-Bianchi P, Giavina-Bianchi M, Tanno LK, Ensina LF, Motta AA, Kalil J. Epileptic seizure after treatment with thiocolchicoside. Ther Clin Risk Manag. 2009 Abstract
  7. De Riu PL, Rosati G, Sotgiu S, Sechi G. Epileptic seizures after treatment with thiocolchicoside. Epilepsia. 2001 Abstract
  8. Sandouk P, Chappey O, d'Yvoire MB, Scherrmann JM. Pharmacokinetics of thiocolchicoside in humans using a specific radioimmunoassay. Ther Drug Monit. 1995 Abstract
  9. Perucca E, Poitou P, Pifferi G. Comparative pharmacokinetics and bioavailability of two oral formulations of thiocolchicoside, a GABA-mimetic muscle relaxant drug, in normal volunteers. Eur J Drug Metab Pharmacokinet. 1995 Abstract
  10. Sandouk P, Bouvier d'Yvoire M, Chretien P, Tillement JP, Scherrmann JM. Single-dose bioavailability of oral and intramuscular thiocolchicoside in healthy volunteers. Biopharm Drug Dispos. 1994 Abstract

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