Last update Jan. 22, 2025

Baclofen

Compatible

Safe product and/or breastfeeding is the best option.

Central acting myorelaxant. Indicated in spasticity associated with degenerative diseases and cerebral palsy. Oral or intrathecal administration.

Excreted in breast milk in clinically insignificant amount, even less after intrathecal administration.(Hara 2018, Almas 2016, Lin 2014, Eriksson 1981)

Neonatal withdrawal syndrome may occur after administration during pregnancy, which is minimized to a small extent by breastfeeding while the mother continues to take baclofen and usually requires administration of baclofen to the newborn.. (Lin 2014, Moran 2004)

Baclofen does not interfere with prolactin levels. (Morosini 1985, Potkin 1978)

Oral use authorized from birth. (AEMPS 2024)

American Academy of Pediatrics: mediation usually compatible with breastfeeding. (AAP 2001)

Alternatives

We do not have alternatives for Baclofen since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Baclofen in other languages or writings:

Group

Baclofen belongs to this group or family:

Tradenames

Main tradenames from several countries containing Baclofen in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 70 - 85 %
Molecular weight 214 daltons
Protein Binding 30 %
VD 0.7 l/Kg
pKa 3.89 -
Tmax 2 - 3 hours
T½ 2 - 6 hours
M/P ratio 0.7 -
Theoretical Dose 0.021 - 0.048 mg/Kg/d
Relative Dose 1.7 - 6.9 %
Ped.Relat.Dose 1.0 - 2.8 %

References

  1. AEMPS. Baclofeno. Ficha técnica. 2024 Full text (in our servers)
  2. Hara T, Nakajima M, Sugano H, Karagiozov K, Hirose E, Goto K, Arai H. Pregnancy and Breastfeeding during Intrathecal Baclofen Therapy - A Case Study and Review. NMC Case Rep J. 2018 Jun 25;5(3):65-68. Abstract Full text (link to original source)
  3. Almas S, Vance J, Baker T, Hale T. Management of Multiple Sclerosis in the Breastfeeding Mother. Mult Scler Int. 2016;2016:6527458. Abstract Full text (link to original source) Full text (in our servers)
  4. Lin HH, Barton N, Wiegand TJ. Prevention of neonatal abstinence syndrome in the setting of intrauterine baclofen exposure. 014 ACMT Annual Scientific Meeting—March 28–30, 2014 Phoenix, AZ, USA. J. Med. Toxicol. 10, 65–99 (2014).Platform Session #53. Full text (link to original source) Full text (in our servers)
  5. Lin HH, Barton N, Wiegand TJ. Baclofen distribution into breast milk-a potential for toxicity? 2014 ACMT Annual Scientific Meeting—March 28–30, 2014 Phoenix, AZ, USA. J. Med. Toxicol. 10, 65–99 (2014).Platform Session #54. Full text (link to original source) Full text (in our servers)
  6. AEMPS Baclofeno intratecal Ficha técnica 2012 Full text (link to original source) Full text (in our servers)
  7. IQB Baclofeno oral Ficha técnica 2008 Full text (link to original source) Full text (in our servers)
  8. Moran LR, Almeida PG, Worden S, Huttner KM. Intrauterine baclofen exposure: a multidisciplinary approach. Pediatrics. 2004 Abstract
  9. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  10. Morosini PP, Carletti P, Sarzani R, Ferretti GF, Marchesi GF, Nardi B. [Prolactin after baclofen in healthy subjects and prolactinoma patients]. Boll Soc Ital Biol Sper. 1985 Abstract
  11. Eriksson G, Swahn CG. Concentrations of baclofen in serum and breast milk from a lactating woman. Scand J Clin Lab Invest. 1981 Abstract
  12. Potkin SG, Gillin JC, Rogol A, Nasrallah HA, Wyatt RJ. Baclofen: lack of effect on human plasma prolactin. Commun Psychopharmacol. 1978 Abstract

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