Last update Jan. 3, 2022

Thiabendazole

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is an anthelmintic, derived from benzimidazole, with activity against most nematode worms. Withdrawn from the market in many countries due to less toxic, safer and more effective alternatives. Oral administration twice a day for one or two days.

Since the last update we have not found any published data on its excretion in breast milk.

The paucity of known pharmacokinetic data does not allow prediction of its excretion in human milk.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

 

Alternatives

  • Mebendazole ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Pyrantel Embonate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Thiabendazole is also known as


Thiabendazole in other languages or writings:

Groups

Thiabendazole belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Thiabendazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 201 daltons
VD 2.76 l/Kg
pKa 10.28 -
Tmax 1 - 2 hours
1 - 2 hours

References

  1. Porto I. Antiparasitic drugs and lactation: focus on anthelmintics, scabicides, and pediculicides. J Hum Lact. 2003 Abstract
  2. Bauer LA, Raisys VA, Watts MT, Ballinger J. The pharmacokinetics of thiabendazole and its metabolites in an anephric patient undergoing hemodialysis and hemoperfusion. J Clin Pharmacol. 1982 May-Jun;22(5-6):276-80. Abstract

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