Last update Dec. 29, 2020


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a nonsteroidal anti-inflammatory drug which possesses both analgesic and antipyretic activities.
It is indicated for the relief of signs and symptoms related to osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder and acute gouty arthritis.
Administration orally twice a day.

At the time this last update was completed, we did not find published data regarding the excretion of this substance through breast milk.

Its high plasma protein binding make it very unlikely its excretion into breast milk in significant amount.

Until there is further published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in cases of prematurity.


  • Flurbiprofen (Safe substance and/or breastfeeding is the best option.)
  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Indomethacin; Indometacin (Safe substance and/or breastfeeding is the best option.)
  • Paracetamol (Safe substance and/or breastfeeding is the best option.)
  • Piroxicam (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sulindac in other languages or writings:


Main tradenames from several countries containing Sulindac in its composition:


Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 356 daltons
Protein Binding 93 - 98 %
pKa 4.09 -
Tmax 3 - 5 hours
7.8 (Metab: 16.4) hours


  1. Teva. Sulindac. Drug Summary. 2011 Full text (in our servers)
  2. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med. 2000 Abstract Full text (link to original source) Full text (in our servers)

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