Last update Jan. 29, 2022
Sulphamide similar to sulfamethoxazole. It is used together with other antibacterials in the treatment of intestinal infections and in intestinal decontamination prior to surgery.
Since the last update we have not found published data on its excretion in breastmilk. Its very low oral bioavailability minimizes both the excretion in breast milk and the passage into plasma of the infant from ingested breast milk
It remains in the intestine without being absorbed; only 5% does so in the form of sulfathiazole (Martindale, acc.2022). Its very low oral bioavailability minimizes both excretion in breast milk and passage to infant plasma from ingested breast milk.
Sulphamides are excreted in small amounts in breast milk: 6 to 94 micrograms/ml, 1.6% of the total dose. (Briggs 2015)
Reports of adverse effects are rare (Briggs 2015). Avoid in suspected glucose-6-phosphate dehydrogenase deficiency.
Due to the greater toxicity than other antimicrobials and their high acquired resistance, the use of sulfonamides is currently very scarce (Pérez 2003). Product with very few bibliographic and/or very old references, marketed in few countries.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America
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