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A short-acting sulfonamide with similar properties to sulfamethoxazole. Rarely administered systemically due to its toxicity (ChemIDplus/ant. Toxnet 2009). Used topically along with other medications for the treatment of vaginal, dermatological, ocular, otic and gastrointestinal infections.
Since the last update we have not found published data on its excretion in breastmilk.
Sulfonamides are excreted in small amounts in breastmilk: 6 to 94 micrograms/ml, 1.6% of the total dose. (Briggs 2017)
Reports of adverse effects are rare (Briggs 2017). An old publication reports cases of diarrhea and rash in children breastfed by mothers who were being treated with sulfathiazole. (Von Friesen 1951).
Due to the greater toxicity than that of other antimicrobials and their high acquired resistance, the use of sulfonamides is currently very scarce. (Perez 2003)
TOPICAL USE IS COMPATIBLE WITH BREASTFEEDING
The small dose and poor plasma absorption of most topical ophthalmological, otic and dermatological preparations make it unlikely that significant amounts will transfer into breastmilk.
Sulfathiazole is absorbed in very small amounts through the dermis (Waud 1944) and the intestine. (Lasca 2018)
Do not apply to the breast in order to prevent the infant from ingesting it; if necessary, apply after a feed and clean well with water before the next one.