Last update Nov. 17, 2014

Mupirocin

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Because of a small dose used and low absorption through skin (less than 1%), excretion into breast milk in significant amount is unlikely.

Despite of it is well absorbed by the gut, it is rapidly and completely metabolized into Monic acid which is a non-active metabolite. However, whenever used on the nipple, it is recommended remove excess of cream by using a gauze.

Effectiveness is not higher than purified Lanolin for treatment of sore or cracked nipples. Results in the treatment of nipple infection due to Staph. aureus are less encouraging than with the use of oral antibiotics.

Caution should be observed with the application of creams, gels and other products that are indicated for local use if they contain paraffin (Mineral oil) to avoid absorption by the infant.

Alternatives

We do not have alternatives for Mupirocin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Mupirocin is also known as


Group

Mupirocin belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 501 daltons
Protein Binding 97 %
T½ 0.3 - 0.5 hours

References

  1. Dennis CL, Schottle N, Hodnett E, McQueen K. An all-purpose nipple ointment versus lanolin in treating painful damaged nipples in breastfeeding women: a randomized controlled trial. Breastfeed Med. 2012 Dec;7(6):473-9. Abstract
  2. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  3. AEMPS. Mupirocina. Ficha técnica. 2007 Full text (in our servers)
  4. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006 Abstract
  5. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  6. Livingstone V, Stringer LJ. The treatment of Staphyloccocus aureus infected sore nipples: a randomized comparative study. J Hum Lact. 1999 Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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