Last update July 31, 2018


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Alpha-1 adrenergic blocker indicated in benign prostatic hyperplasia (BPH) in adult males.
Oral administration once a day.

Since the last update we have not found published data on its excretion in breastmilk.

Its high percentage of protein binding (EMA 2018) makes transfer into milk in significant amounts unlikely.

Its low oral bioavailability, reduced further with the consumption of fatty foods, such as milk (EMA 2018), hinders its transfer to the infant’s plasma from the breastmilk ingested, except in premature babies and the immediate neonatal period when there may be greater intestinal permeability.

Possible side effects are not serious or frequent (EMA 2018).


We do not have alternatives for シロドシン.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

シロドシン is Silodosin in Japanese.

Is written in other languages:

シロドシン is also known as


Main tradenames from several countries containing シロドシン in its composition:


Variable Value Unit
Oral Bioavail. 32 %
Molecular weight 496 daltons
Protein Binding 96.6 %
VD 0.81 l/Kg
pKa 14.9 -
Tmax 2.5 ( 1 - 3 ) hours
11 - 24 hours


  1. EMA. Silodosin. Drug Summary. 2018 Full text (in our servers)
  2. EMA. Silodosina. Ficha técnica. 2018 Full text (in our servers)

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