Last update Feb. 5, 2022

生物素

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Biotin, vitamin B7 or vitamin H is an essential coenzyme in the metabolism of fat and in other metabolic reactions. It is classified within the group of vitamin B.

At the date of the last update, there was no published data available on its excretion in human milk but, given its lack of toxicity, it is unlikely that there is any risk of its consumption at recommended doses.

Breastfeeding can be continued even with high doses (2.5 mg/day) of biotin. (Sauberan 2019)

Biotin is found in the non-fat portion of breastmilk in an amount of 5 to 10 μg/L (Sauberan 2019, Sakurai 2005, Mock 1992) with a higher concentration in mature milk than in colostrum, but without significant differences between preterm milk and full-term milk (Salmenperä 1985, Ford 1983), nor between different countries. (Nguyen 2020)

Biotin requirements are 10 to 200 μg daily according to some authors and 30 to 100 μg according to others: 5 to 15 μg in infants, 20 to 30 μg in children, 30 μg in pregnant women and 35 μg in nursing mothers. (Saleem 2021, Sauberan 2019, Ares 2015, Perry 2014, UMMC 2013, Zempleni 1999)

Biotin is widely distributed in food. Foods rich in biotin are egg yolk, liver, cereals (wheat, oats), vegetables (spinach, mushrooms), rice, dairy products, and human milk; intestinal bacteria can produce biotin (Saleem 2021), so its deficiency is very rare under adequate nutritional conditions and there are no known cases of poisoning even with doses higher than those of daily needs.

With a varied and balanced diet, vitamin supplements are not needed for most women.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

生物素 is Biotin, Vitamin B7, Vitamin H in Chinese.

Is written in other languages:

生物素 is also known as

Group

生物素 belongs to this group or family:

Tradenames

Main tradenames from several countries containing 生物素 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 - 100 %
Molecular weight 244 daltons
Protein Binding 80 %
pKa 4.4 -

References

  1. Saleem F, Soos MP. Biotin Deficiency. 2021 Apr 14. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Abstract
  2. Nguyen MTT, Kim J, Lee H, Won S, Kim Y, Jung JA, Li D, To XHM, Huynh KTN, Le TV, Israr B, An HJ, Kim J. A Comparison of Vitamin and Lutein Concentrations in Breast Milk from Four Asian Countries. Nutrients. 2020 Jun 17;12(6). pii: E1794. Abstract
  3. Sauberan JB. High-Dose Vitamins. Breastfeed Med. 2019 Apr 30. Abstract
  4. Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia, ¿necesitan las madres lactantes suplementos nutricionales? [The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?] An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  5. Perry CA, West AA, Gayle A, Lucas LK, Yan J, Jiang X, Malysheva O, Caudill MA. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet. J Nutr. 2014 Abstract
  6. UMMC. University of Maryland Medical Center. Vitamin H (Biotin). Medical Reference Guide. 2013 Full text (link to original source) Full text (in our servers)
  7. Sakurai T, Furukawa M, Asoh M, Kanno T, Kojima T, Yonekubo A. Fat-soluble and water-soluble vitamin contents of breast milk from Japanese women. J Nutr Sci Vitaminol (Tokyo). 2005 Abstract
  8. Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem. 1999 Abstract
  9. Mock DM, Mock NI, Dankle JA. Secretory patterns of biotin in human milk. J Nutr. 1992 Abstract
  10. Salmenperä L, Perheentupa J, Pispa JP, Siimes MA. Biotin concentrations in maternal plasma and milk during prolonged lactation. Int J Vitam Nutr Res. 1985 Abstract
  11. Ford JE, Zechalko A, Murphy J, Brooke OG. Comparison of the B vitamin composition of milk from mothers of preterm and term babies. Arch Dis Child. 1983 Abstract Full text (link to original source) Full text (in our servers)

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