Last update Aug. 21, 2021

Biotin, Vitamin B7, Vitamin H

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Biotin, vitamin B7 or vitamin H is an essential coenzyme for fat metabolism and other metabolic reactions, which is classified among the vitamin B group.

Recommended daily allowance is 10 to 200 μg according to some authorities and 30 to 100 μg to some others: 5 at15 μg for infants, 20 to 30 μg for children, 30 μg for pregnant women and 35 μg for lactating mothers (Saleem 2021, Sauberan 2019, Ares 2015, Perry 2014, UMMC 2013, Zempleni 1999).

Biotin is found in the non-fat fraction of breast milk in an amount of 5 to 10 μg/L (Sauberan 2019, Sakurai 2005, Mock 1992) with a higher concentration in mature milk than in colostrum but without significant differences between preterm milk and full-term milk (Salmenperä 1985, Ford 1983), nor between different countries (Nguyen 2020).

Biotin is widely distributed in many foods. Foods rich in biotin are egg yolk, liver, cereals (wheat, oats), vegetables (spinach, mushrooms), rice, dairy products, and breast milk; intestinal bacteria can produce biotin (Saleem 2021), so its deficiency is very rarey among people who are on adequate diet, nor any case of intoxication is known even with higher doses than recommended for daily intake.

At date of latest update, relevant data related to breastfeeding were not found. However, because lack of toxicity a risk due to consumption at recommended dose is unlikely.

Breastfeeding can be continued even with high doses (2.5 mg/day) of biotin (Sauberan 2019).

With an adequate and comprehensive diet, the consumption of vitamin supplementation is not necessary.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Biotin, Vitamin B7, Vitamin H is also known as


Biotin, Vitamin B7, Vitamin H in other languages or writings:

Group

Biotin, Vitamin B7, Vitamin H belongs to this group or family:

Tradenames

Main tradenames from several countries containing Biotin, Vitamin B7, Vitamin H in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 - 100 %
Molecular weight 244 daltons
Protein Binding 80 %
pKa 4,4 -

References

  1. Saleem F, Soos MP. Biotin Deficiency. 2021 Apr 14. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Abstract
  2. Nguyen MTT, Kim J, Lee H, Won S, Kim Y, Jung JA, Li D, To XHM, Huynh KTN, Le TV, Israr B, An HJ, Kim J. A Comparison of Vitamin and Lutein Concentrations in Breast Milk from Four Asian Countries. Nutrients. 2020 Jun 17;12(6). pii: E1794. Abstract
  3. Sauberan JB. High-Dose Vitamins. Breastfeed Med. 2019 Apr 30. Abstract
  4. Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia, ¿necesitan las madres lactantes suplementos nutricionales? [The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?] An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  5. Perry CA, West AA, Gayle A, Lucas LK, Yan J, Jiang X, Malysheva O, Caudill MA. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet. J Nutr. 2014 Abstract
  6. UMMC. University of Maryland Medical Center. Vitamin H (Biotin). Medical Reference Guide. 2013 Full text (link to original source) Full text (in our servers)
  7. Sakurai T, Furukawa M, Asoh M, Kanno T, Kojima T, Yonekubo A. Fat-soluble and water-soluble vitamin contents of breast milk from Japanese women. J Nutr Sci Vitaminol (Tokyo). 2005 Abstract
  8. Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem. 1999 Abstract
  9. Mock DM, Mock NI, Dankle JA. Secretory patterns of biotin in human milk. J Nutr. 1992 Abstract
  10. Salmenperä L, Perheentupa J, Pispa JP, Siimes MA. Biotin concentrations in maternal plasma and milk during prolonged lactation. Int J Vitam Nutr Res. 1985 Abstract
  11. Ford JE, Zechalko A, Murphy J, Brooke OG. Comparison of the B vitamin composition of milk from mothers of preterm and term babies. Arch Dis Child. 1983 Abstract Full text (link to original source) Full text (in our servers)

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