Last update Dec. 24, 2022

ριμπαβιρίνη; τριμπαβιρίνη;

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Synthetic drug and nucleoside analogue which is structurally related to guanine with antiviral activity. It is used in infants and newborns for treatment of respiratory syncytial virus (RSV) and adenovirus (Ronchi 2014). It is used along with interferon for treatment of hepatitis C, authorized on these cases from the 3 years of life. (Christensen 2014, Durmaz 2012). Oral administration in patients with chronic hepatitis C.

At latest update no published data on excretion into breast milk were found.

Its large volume of distribution makes it unlikely that may occur the passage of significant amounts to the milk, but its very long elimination half-life would favor it

Its low oral bioavailability hinder the passage toward infant’s plasma from ingested milk, except in preterm milk and immediate neonatal period, for which there may be an increased intestinal permeability.

Since it is used as treatment on infants and its pharmacokinetic data are favorable, it should be regarded as compatible with breastfeeding for short-term exposures, however, to be cautiously used on long-term treatments.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity. (Mahadevan 2006)


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

ριμπαβιρίνη; τριμπαβιρίνη; is Ribavirin in Greek.

Is written in other languages:

ριμπαβιρίνη; τριμπαβιρίνη; is also known as

Group

ριμπαβιρίνη; τριμπαβιρίνη; belongs to this group or family:

Tradenames

Main tradenames from several countries containing ριμπαβιρίνη; τριμπαβιρίνη; in its composition:

List of 19 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 45 - 65 %
Molecular weight 244 daltons
Protein Binding 0 %
VD 40 - 69 l/Kg
pKa 11.88 -
Tmax 1 - 2 hours
T½ 120 - 298 hours

References

  1. Christensen VB, Nordly S, Fischler B, Kjær MS, Jørgensen MH. [Hepatitis C infection in children.] Ugeskr Laeger. 2014 Abstract
  2. Ronchi A, Doern C, Brock E, Pugni L, Sánchez PJ. Neonatal adenoviral infection: a seventeen year experience and review of the literature. J Pediatr. 2014 Abstract
  3. Le Campion A, Larouche A, Fauteux-Daniel S, Soudeyns H. Pathogenesis of hepatitis C during pregnancy and childhood. Viruses. 2012 Abstract Full text (link to original source) Full text (in our servers)
  4. Durmaz O. Hepatitis C infection in childhood. Clin Res Hepatol Gastroenterol. 2012 Abstract
  5. Arshad M, El-Kamary SS, Jhaveri R. Hepatitis C virus infection during pregnancy and the newborn period--are they opportunities for treatment? J Viral Hepat. 2011 Abstract
  6. Ventre K, Randolph A. WITHDRAWN: Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children. Cochrane Database Syst Rev. 2010 Abstract
  7. Ksiezakowska K, Laszczyk M, Wilczyński J, Nowakowska D. [SARS-CoV infection and pregnancy]. Ginekol Pol. 2008 Abstract
  8. Fischler B. Hepatitis C virus infection. Semin Fetal Neonatal Med. 2007 Abstract
  9. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  10. Davison C, Ventre KM, Luchetti M, Randolph AG. Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysis. Pediatr Crit Care Med. 2004 Abstract Full text (link to original source) Full text (in our servers)

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