Last update Jan. 17, 2021

Repaglinide

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a meglitinide antidiabetic. It has a different structure from the sulfonylureas, but a similar mechanism of action. It induces endogenous insulin secretion and can cause hypoglycemia.
Indicated in the treatment of type 2 diabetes.
Oral administration, before meals, two or three times a day.

We did not find published data regarding the excretion of this substance through breast milk at the time this last update was completed.

Its pharmacokinetic characteristics (very high plasma protein binding, moderately elevated molecular weight, large volume of distribution and short half life) make it very unlikely its excretion into breast milk in significant amounts.

Diet, exercise, and breastfeeding improve blood sugar levels.


See below the information of this related product:

  • Maternal Diabetes mellitus (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Acarbose (Safe substance and/or breastfeeding is the best option.)
  • Glibenclamide (Safe substance and/or breastfeeding is the best option.)
  • Glipizide (Safe substance and/or breastfeeding is the best option.)
  • Hypocaloric Diet (Safe substance and/or breastfeeding is the best option.)
  • Insulin (Safe substance and/or breastfeeding is the best option.)
  • Maternal Sport (Safe substance and/or breastfeeding is the best option.)
  • Metformin Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Miglitol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Repaglinide in other languages or writings:

Group

Repaglinide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Repaglinide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 56 - 63 %
Molecular weight 453 daltons
Protein Binding 98 %
VD 0.44 l/Kg
pKa 3.68 -
Tmax 1 (0.5 - 1.4) hours
1 hours

References

  1. EMA. Repaglinide. Drug Summary. 2020 Full text (in our servers)
  2. AEMPS. Repaglinida. Ficha técnica. 2020 Full text (in our servers)

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