Last update Jan. 15, 2021

Glipizide

Compatible

Safe substance and/or breastfeeding is the best option.

Sulfonylurea that stimulates endogenous insulin secretion. May cause hypoglycemia.
Indicated in the treatment of type 2 diabetes.
Oral administration in one or two daily doses.

Its pharmacokinetic data (moderately high molecular weight and very high percentage of plasma protein binding) explain the zero or negligible passage into breast milk observed (Feig 2005).
The infants' blood glucose levels were normal (Feig 2005).

Experts authors consider the use of this medication to be safe during breastfeeding (Serrano 2015, Glatstein 2009, Feig 2007).

Diet, exercise, and breastfeeding improve blood sugar levels.


See below the information of this related product:

  • Maternal Diabetes mellitus (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Acarbose (Safe substance and/or breastfeeding is the best option.)
  • Glibenclamide (Safe substance and/or breastfeeding is the best option.)
  • Hypocaloric Diet (Safe substance and/or breastfeeding is the best option.)
  • Insulin (Safe substance and/or breastfeeding is the best option.)
  • Maternal Sport (Safe substance and/or breastfeeding is the best option.)
  • Metformin Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Miglitol (Safe substance and/or breastfeeding is the best option.)
  • Tolbutamide (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Glipizide in other languages or writings:

Group

Glipizide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Glipizide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 80 - 100 %
Molecular weight 446 daltons
Protein Binding 98 %
VD 0.14 l/Kg
pKa 4.32 -
Tmax 1 - 3 hours
T½ 2 - 4 hours
M/P ratio ≈ 0 -

References

  1. Pfizer. Glipizida. Ficha técnica. 2016 Full text (in our servers)
  2. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Jan 20;144(2):73-9. Abstract
  3. Glatstein MM, Djokanovic N, Garcia-Bournissen F, Finkelstein Y, Koren G. Use of hypoglycemic drugs during lactation. Can Fam Physician. 2009 Abstract Full text (link to original source) Full text (in our servers)
  4. Pfizer. Glipizide. Drug Summary. 2008 Full text (in our servers)
  5. Feig DS, Briggs GG, Koren G. Oral antidiabetic agents in pregnancy and lactation: a paradigm shift? Ann Pharmacother. 2007 Abstract
  6. Feig DS, Briggs GG, Kraemer JM, Ambrose PJ, Moskovitz DN, Nageotte M, Donat DJ, Padilla G, Wan S, Klein J, Koren G. Transfer of glyburide and glipizide into breast milk. Diabetes Care. 2005 Abstract Full text (link to original source) Full text (in our servers)

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