Last update July 29, 2024

Quinidine

Compatible

Safe substance and/or breastfeeding is the best option.

Quinidine is a D-isomer of quinine found in the bark of the Cinchona tree and similar plant species. It is a class Ia antiarrhythmic with antimuscarinic and alpha-adrenergic receptor blocking properties.  It is used in the treatment of supraventricular and ventricular arrhythmias, including atrial fibrillation and atrial flutter. Can be used as an alternative to quinine in the treatment of malaria when quinine is not available. Oral administration 3-4 times daily.

Excreted in breast milk in clinically insignificant amount: a single study in one mother. (Hill 1979)

Milk production should be monitored, as its antimuscarinic properties may inhibit prolactin secretion.

Expert authors consider that the use of this medication during lactation is probably compatible. (Hale, Tan 2001)

American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)

Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)

Alternatives

  • Procainamide Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Propranolol (Safe substance and/or breastfeeding is the best option.)
  • Quinine (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Quinidine is also known as


Quinidine in other languages or writings:

Group

Quinidine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Quinidine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 99 %
Molecular weight 324 daltons
Protein Binding 80 %
Tmax 2 hours
T½ 8 hours
M/P ratio 0.7 -
Theoretical Dose 1.23 mg/Kg/d
Relative Dose 4.1 %
Ped.Relat.Dose 2.5 - 8.2 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  4. Tan HL, Lie KI. Treatment of tachyarrhythmias during pregnancy and lactation. Eur Heart J. 2001 Abstract Full text (link to original source) Full text (in our servers)
  5. Hill LM, Malkasian GD Jr. The use of quinidine sulfate throughout pregnancy. Obstet Gynecol. 1979 Sep;54(3):366-8. Abstract

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