Last update July 21, 2023
Limited compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Psilocybine is also known as
Psilocybine in other languages or writings:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 50 | % |
Molecular weight | 284 | daltons |
pKa | 1.74 | - |
Tmax | 1.3 - 1.7 | hours |
T½ | 2.7 - 3 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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Psilocin and psilocybin are indole alkaloids obtained from the Mexican mushroom Psilocybe mexicana and other mushrooms (Psilocybe semilanceata o seta mágica, Stropharia cubensis, Conocybe, Panaeolus, Gymnopilus, Stropharia, Pluteus and Panaeolina). Psilocybin is metabolised in the body to the active form psilocin. It has psychedelic (NIH 2023), hallucinogenic and sympathomimetic properties similar to those of lysergide (LSD) and mescaline, but less potent. Its hallucinogenic effects last up to 6 hours. It has no therapeutic use. Oral or smoked administration. (Martindale, Dinis-Oliveira 2017, Tylš 2014, Passie 2002)
At the date of the last update we did not find any published data on its excretion in breast milk.
The paucity of published pharmacokinetic data does not allow prediction of the amount of possible excretion into breast milk.
May produce increased prolactin secretion. (Holze 2022, Hasler 2004)
It is known from pharmacokinetics that after 5 elimination half-lives (T½) 96.9% of an ingested substance is eliminated from the body, and after 7 T½ the plasma concentrations of the substance are negligible and would constitute the safe waiting period for resuming breast-feeding after taking Psilocybine.
Taking the published T½ (3 h) as a reference, this 7 T½ would correspond to 21 hours. In the meantime, breast milk should be expressed and discarded regularly if breastfeeding is to be resumed.
Psychotropic drugs of abuse render the mother incapable of caring for her child, endangering the life and health of both.
Bed-sharing with the baby is not recommended if you are taking this drug.