Last update Feb. 3, 2025

Pristinamycin

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Pristinamycin is a streptogramin antibacterial produced by the growth of Streptomyces pristina spiralis. Its semi-synthetic derivatives are Quinupristin and Dalfopristin. Indicated for the treatment of staphylococcal infections. Oral administration two to three times daily.

At the time of the last update we found no published data on its excretion in breast milk.

Product with few bibliographic references and little known pharmacological data. 

Side effects are rare, mild and reversible (gastrointestinal disturbances, joint or muscle pain, rash).

Until further published data on this drug in relation to breastfeeding are known, safer alternatives may be preferable, especially during the neonatal period and in case of prematurity.
 


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Pristinamycin in other languages or writings:

Group

Pristinamycin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Pristinamycin in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 867 daltons
Protein Binding 40 - 80 %
Tmax 3.3 ± 1.8 hours
4.0 ± 2.8 hours

References

  1. Sanofi. Pristinamicyn. Drug Summary. 2012 Full text (in our servers)
  2. Koechlin C, Kempf JF, Jehl F, Monteil H. Single oral dose pharmacokinetics of the two main components of pristinamycin in humans. J Antimicrob Chemother. 1990 Apr;25(4):651-6. Abstract

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