Last update Jan. 2, 2022


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

In polymer of denatured gelatin derived polypeptides linked with urea bridges. It is a plasma substitute that is used as a plasma volume expander in the treatment of hypovolemic shock. Administration by intravenous infusion.

Since the last update we have not found any published data on its excretion in breast milk.

Its very high molecular weight make it highly unlikely that significant quantities will pass into breast milk.

Its null oral bioavailability makes it difficult for it to pass to the infant plasma from ingested breast milk, except in premature infants and in the immediate neonatal period in which there may be greater intestinal permeability.

List of WHO essential medicines: compatible with breastfeeding. (WHO / UNICEF 2002)


We do not have alternatives for Polygeline since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Polygeline is also known as

Polygeline in other languages or writings:


Polygeline belongs to this group or family:


Main tradenames from several countries containing Polygeline in its composition:


Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 30.000 - 35.000 daltons
VD 0.11 l/Kg
Tmax 4 - 6 hours
5 - 6 hours


  1. Lozano Losada, Abner. Coloides. Rev. Col. Anest. 2005 Abstract Full text (link to original source)
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by AELAMA of Spain

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