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Pioglitazone is a thiazolidinedione used in conjunction with diet and exercise to normalize blood glucose levels in adults with type 2 diabetes mellitus. It is administered orally once daily.
At the time of the last update, we found no published data on its excretion in breast milk.
Its pharmacokinetic data (very high percentage of binding to plasma proteins and large volume of distribution) make it very unlikely to pass into breast milk in clinically significant quantities.
Pending further published data on this drug in relation to lactation, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.
Some health agencies (France, Germany) have recommended the suspension of marketing of pioglitazone for being associated with an increased risk of cancer of the bladder. (IARC 2016)
Thiazolidinediones increase insulin sensitivity. Oral antidiabetics are not useful in type 1 diabetes. In type 2 diabetes, diet, exercise and breastfeeding will improve blood glucose levels.
See below the information of this related product: