Last update Aug. 19, 2021
Long-acting benzodiazepine with properties similar to diazepam.
Active metabolite of clorazepate, diazepam, halazepam, medazepam, pinazepam and prazepam. It is metabolized to oxazepam.
Indicated in anxiety disorder and insomnia.
It is excreted in breast milk in an amount that could be significant (Dusci 1990, Wesson 1985, Pacifici 1984, Rey 1979).
Levels that could be significant have been measured in plasma from infants whose mothers took it (Dusci 1990, Wesson 1985, Rey 1979).
Product with very few bibliographical references and marketed in very few countries.
The occasional and low-dose use of benzodiazepines is compatible with breastfeeding (Kelly 2012, Rubin 2004, Iqbal 2002, Hägg 2000, Borgatta 1997, McElhatton 1994, Lee 1993, Kanto 1982).
Choose short-acting benzodiazepines and use the lowest effective dose (Rowe 2013), especially during the neonatal period and in prematurity, as they can accumulate in the infant during chronic use (Sachs 2013).
It is advisable to monitor drowsiness and adequate feeding of the infant.
Bed-sharing with the baby is not recommended if this medicine is being taken due to increased risk of suffocation or sudden infant death (UNICEF 2018, 2017, 2014 and 2013, Landa 2012, ABM 2008, UNICEF 2006).
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America
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