Last update Aug. 18, 2021

Lorazepam

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Short-acting benzodiazepine. Indications: anxiety, insomnia.
Oral administration 1 to 3 times a day.

It is excreted in breast milk in insignificant amounts (Nishimura 2021, Lemmer 2007, Summerfield 1985, Whitelaw 1981) and no problems have been observed in infants of mothers taking it at the normal dose (Nishimura 2021, Kelly 2012, Johnstone 1982, Whitelaw 1981).

Expert authors consider the use of lorazepam to be safe or very probably safe during breastfeeding (Hale, Lactmed, Uguz 2021, Briggs 2015, Schaefer 2015, Nice 2004).

The occasional and low-dose use of benzodiazepines is compatible with breastfeeding (Kelly 2012, Rubin 2004, Iqbal 2002, Hägg 2000, McElhatton 1994, Lee 1993, Kanto 1982).

Choose short-acting benzodiazepines and use the lowest effective dose (Rowe 2013), especially during the neonatal period and in prematurity, as they can accumulate in the infant during chronic use (Sachs 2013).

It is advisable to monitor drowsiness and adequate feeding of the infant.
Bed-sharing with the baby is not recommended if this medicine is being taken due to increased risk of suffocation or sudden infant death (UNICEF 2018, 2017, 2014 and 2013, Landa 2012, ABM 2008, UNICEF 2006

Alternatives

  • Midazolam ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Oxazepam ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Lorazepam in other languages or writings:

Group

Lorazepam belongs to this group or family:

Tradenames

Main tradenames from several countries containing Lorazepam in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 321 daltons
Protein Binding 85 %
VD 1 l/Kg
Tmax 2 hours
T1/2 12 (10 - 20) hours
M/P ratio 0,2 - 0,3 -
Theoretical Dose 0,0003 - 0,002 mg/Kg/d
Relative Dose 1 - 4,3 %
Ped.Relat.Dose 0,3 - 0,7 %

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263,641

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