Last update Jan. 15, 2019
Very Low Risk
An amino acid with mucolytic properties. It is used orally to treat respiratory catarrh and, at high doses, in the detoxification of paracetamol overdose intravenously and orally.
Since the last review we have not found published data related to breastfeeding.
Its low oral bioavailability complicates transfer to infant plasma via breastmilk, except in premature babies and the immediate neonatal period when there may be increased intestinal permeability.
It is used in newborns and small infants as a mucolytic agent and, at high doses, for detoxification following paracetamol overdose (Brener 2013, Bajorek 2012, Aiyagari 2010, Walls 2007). It is used in various neonatal diseases (Aiyagari 2010, Emil 2004) and is found in combination with other amino acids in intravenous solutions in parenteral nutrition (Soghier 2006).
Since it is virtually devoid of toxicity and is commonly used in neonatology, even at high doses, it is very unlikely to cause problems in breastfeeding (Briggs 2017).
It is considered to be one of the mucolytics of choice during breastfeeding (Schaefer 2007, p 644).
We do not have alternatives for N-acetylcysteine (NAC) since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.
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Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM