Ацетилцистеин

An amino acid with mucolytic properties. It is used orally to treat respiratory catarrh and, at high doses, in the detoxification of paracetamol overdose intravenously and orally.

Since the last review we have not found published data related to breastfeeding.

Its wide volume of distribution make it highly unlikely that significant quantities will pass into breast milk.

Its low oral bioavailability complicates transfer to infant plasma via breastmilk, except in premature babies and the immediate neonatal period when there may be increased intestinal permeability.

It is used in newborns and small infants as a mucolytic agent and, at high doses, for detoxification following paracetamol overdose. ^{(Brener 2013, Bajorek 2012, Aiyagari 2010, Walls 2007)}

It is used in various neonatal diseases ^{(Aiyagari 2010, Emil 2004)} and is found in combination with other amino acids in intravenous solutions in parenteral nutrition. ^{(Soghier 2006)}

Since it is virtually devoid of toxicity and is commonly used in neonatology, even at high doses, it is very unlikely to cause problems in breastfeeding. ^{(Briggs 2017)}

It is considered to be one of the mucolytics of choice during breastfeeding. ^{(Schaefer 2007, p 644)}