Last update Sept. 26, 2014

Methyl Aminolaevulinate Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is locally used together with photo-dynamic therapy (especial blue light) as a treatment of Actinic Dermatitis and Basocelular Carcinoma.

At latest update, relevant information on excretion into breast milk was not found.

Absorption through the skin is very low (0.26 % of administered dose), hence, a low or non-significant level in the mother's plasma should be expected.

In case that a complete elimination of drug would be desired, a time period equivalent to ten times a half-life (Mean time) should be observed after drug administration to resume breastfeeding.

In this case it would be equal to 8-10 hours.

In the mean while, pump-and-dump regularly to maintain milk production.

Do not apply it on the breast or cleanse it thoroughly to keep the baby from swallowing.

Alternatives

We do not have alternatives for Methyl Aminolaevulinate Hydrochloride.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Methyl Aminolaevulinate Hydrochloride is also known as 5-Aminolevulinic Acid. Here it is a list of alternative known names::


Group

Methyl Aminolaevulinate Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Methyl Aminolaevulinate Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 - 60 %
Molecular weight 131 daltons
T½ 0.8 hours

References

  1. EMEA. Ácido 5-aminolevulínico. Ficha técnica 2011 Full text (in our servers)
  2. Sandberg C, Halldin CB, Ericson MB, Larkö O, Krogstad AL, Wennberg AM. Bioavailability of aminolaevulinic acid and methylaminolaevulinate in basal cell carcinomas: a perfusion study using microdialysis in vivo. Br J Dermatol. 2008 Abstract
  3. McLoone N, Donnelly RF, Walsh M, Dolan OM, McLoone S, McKenna K, McCarron PA. Aminolaevulinic acid diffusion characteristics in 'in vitro' normal human skin and actinic keratosis: implications for topical photodynamic therapy. Photodermatol Photoimmunol Photomed. 2008 Abstract
  4. New Zealand Datasheet. Methyl aminolevulinate. Drug Summary. 2008 Full text (in our servers)
  5. SNS. Aminolevulinato de metilo (ALM). Información Terapéutica. 2005 Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America

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