Last update Nov. 10, 2022

Methionine, L-Methionine, DL-Methionine

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is an essential sulfur amino acid that is very abundant in eggs, meat and fish; sesame seeds, Brazil nuts, soybeans, legumes and cereal grains. It is used as an oral dietary supplement and in solutions for parenteral nutrition. It lowers urinary pH and is used in the treatment of urinary tract infections. The use of methionine as an antidote in the treatment of acetaminophen poisoning to prevent hepatotoxicity has been superseded by acetylcysteine. It is metabolised in the liver to ademetionine, and then homocysteine. Oral or intravenous administration.

At the date of the last update, we found no published data on its excretion in breast milk.

Methionine is found in breast milk, but in lower amounts (100 - 200 mg/L) than the other amino acids. (Lawrence 2016, Chavalittamrong 1981)

Authorized use in young infants for parenteral nutrition and treatment of paracetamol poisoning.

The daily requirements of methionine are 15 mg/kg of body weight: 750 to 1,200 mg/day. (FEN 2013, AESAN 2012). At these doses, methionine is compatible with breastfeeding.

High doses of oral methionine can produce elevated plasma homocysteine levels, nausea, vomiting, drowsiness, and irritability, and psychiatric symptoms in vulnerable people. (Martindale, Garlick 2006, Goren 2004)

Alternatives

We do not have alternatives for Methionine, L-Methionine, DL-Methionine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Methionine, L-Methionine, DL-Methionine in other languages or writings:

Tradenames

Main tradenames from several countries containing Methionine, L-Methionine, DL-Methionine in its composition:

  • Dertrase™. Contains other elements than Methionine, L-Methionine, DL-Methionine in its composition
  • Metiofitina™. Contains other elements than Methionine, L-Methionine, DL-Methionine in its composition
  • Pilopeptan Woman™. Contains other elements than Methionine, L-Methionine, DL-Methionine in its composition
  • Quadevit (Квадевит)™. Contains other elements than Methionine, L-Methionine, DL-Methionine in its composition
  • Seidurol pH™. Contains other elements than Methionine, L-Methionine, DL-Methionine in its composition

Pharmacokinetics

Variable Value Unit
Molecular weight 149 daltons
1 - 1.5 hours

References

  1. FEN - Fundación Española de la Nutrición. Libro Blanco de la Nutrición en España. - 2013 Full text (link to original source)
  2. AESAN. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre condiciones de uso de determinadas sustancias distintas de vitaminas, minerales y plantas para ser empleadas en complementos alimenticios - 1. Revista del comité científico nº 17. 2012 Full text (in our servers)
  3. Garlick PJ. Toxicity of methionine in humans. J Nutr. 2006 Jun;136(6 Suppl):1722S-1725S. Abstract
  4. Gören JL, Stoll AL, Damico KE, Sarmiento IA, Cohen BM. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy. 2004 Nov;24(11):1501-7. Abstract
  5. Chavalittamrong B, Suanpan S, Boonvisut S, Chatranon W, Gershoff SN. Protein and amino acids of breast milk from Thai mothers. Am J Clin Nutr. 1981 Jun;34(6):1126-30. Abstract

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