Last update June 10, 2018

Homocysteine-Thiolactone

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

A thiolactone derivative mucolytic agent of the natural amino acid homocysteine indicated in chronic obstructive bronchitis (CECMED 2017). Administered orally every 12 hours.

Since the last update we have not found published data on its excretion in breastmilk.

Its short half-life makes transfer to milk in significant quantities unlikely.

Side effects are gastrointestinal and mild.

This drug has very few bibliographic references and its effectiveness has not been proven (Cazzola 2018, Welsh 2015, Irwin 1993).

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

If you wish to minimize exposure, you should wait about 3 hours to breastfeed after administration.

Alternatives

  • Acetylcysteine (Safe substance and/or breastfeeding is the best option.)
  • Ambroxol (Safe substance and/or breastfeeding is the best option.)
  • Bromhexine (Safe substance and/or breastfeeding is the best option.)
  • Carbocisteine (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Homocysteine-Thiolactone is also known as Erdosteine.


Homocysteine-Thiolactone in other languages or writings:

Group

Homocysteine-Thiolactone belongs to this group or family:

Tradenames

Main tradenames from several countries containing Homocysteine-Thiolactone in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Alta - Hig %
Molecular weight 249 daltons
Protein Binding 65 %
Tmax 1.2 hours
T½ 1.5 hours

References

  1. Cazzola M, Calzetta L, Page C, Rogliani P, Matera MG. Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis. Pulm Pharmacol Ther. 2018 Abstract
  2. CECMED. Erdosteína (Dostein). Ficha técnica. 2017 Full text (in our servers)
  3. Welsh EJ, Evans DJ, Fowler SJ, Spencer S. Interventions for bronchiectasis: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2015 Abstract
  4. Irwin RS, Curley FJ, Bennett FM. Appropriate use of antitussives and protussives. A practical review. Drugs. 1993 Abstract

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