Last update Aug. 28, 2020

Losartan Potassium

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is an angiotensin II receptor antagonist with antihypertensive activity.
It is indicated in the treatment of hypertension and in heart failure.
Oral administration once a day

At latest update, relevant published data on excretion into breast milk were not found.

A high protein-binding capacity makes excretion into breast milk unlikely. In addition, a low oral bioavailability makes difficult the absorption towards the infant's plasma from ingested milk (Kearney 2018), except in prematures or newborns who may show an increased absorption.

Until more data on this medication is available, safer alternative drugs are preferred (Rowe 2013), especially in premature babies or during the neonatal period.

Alternatives

  • Candesartan Cilexetil ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Captopril ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Enalapril ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Quinapril Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Losartan Potassium in other languages or writings:

Group

Losartan Potassium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Losartan Potassium in its composition:

List of 17 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 33 %
Molecular weight 461 daltons
Protein Binding 99 %
VD 0.5 l/Kg
Tmax 1 - 3 hours
T½ 2 - 9 hours

References

  1. Kearney L, Wright P, Fhadil S, Thomas M. Postpartum Cardiomyopathy and Considerations for Breastfeeding. Card Fail Rev. 2018 Abstract Full text (link to original source) Full text (in our servers)
  2. Merck. Losartan. Drug Summary 2013 Full text (in our servers)
  3. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  4. AEMPS. Losartan. Ficha técnica. 2011 Full text (in our servers)
  5. Tamargo j, Caballero R, Gómez R, Núñez L, Vaquero M y Delpón E. Características farmacológicas de los ARA-II. ¿Son todos iguales?. Rev Esp Cardiol Supl. 2006;6:10C-24C. 2006 Full text (in our servers)

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