Last update Oct. 17, 2024

أكاربوز

Compatible

Safe product and/or breastfeeding is the best option.

It is an alpha-glucosidase inhibitor that acts within the gastrointestinal tract with little or no absorption, decreasing intestinal glucose absorption. Very low risk of hypoglycaemia in monotherapy. Oral administration in three daily doses before meals.

At the time of last update, we found no published data on its excretion in breast milk.

Its pharmacokinetic data (moderately high molecular weight and very low intestinal absorption) make passage into milk of significant amounts unlikely. (Serrano 2014, Everett 1997)

Diet, exercise and breastfeeding improve blood glucose levels.


See below the information of this related product:

  • Maternal Diabetes mellitus (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Glibenclamide (Safe product and/or breastfeeding is the best option.)
  • Glipizide (Safe product and/or breastfeeding is the best option.)
  • Hypocaloric Diet (Safe product and/or breastfeeding is the best option.)
  • Insulin (Safe product and/or breastfeeding is the best option.)
  • Maternal Sport (Safe product and/or breastfeeding is the best option.)
  • Metformin Hydrochloride (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

أكاربوز is Acarbose in Arabic.

Is written in other languages:

أكاربوز is also known as

Groups

أكاربوز belongs to these groups or families:

Tradenames

Main tradenames from several countries containing أكاربوز in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0.7 - 2 %
Molecular weight 646 daltons
VD 0.3 l/Kg
Tmax 1 hours
T½ 2 - 3 hours

References

  1. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Jan 20;144(2):73-9. Abstract
  2. Davis C. Acarbose. Drug Summary. 2015 Full text (in our servers)
  3. AEMPS. Acarbosa. Ficha técnica. 2009 Full text (in our servers)
  4. Nice FJ, De Eugenio D, Dimino TA, Freeny IC, Rovnack MB, Gromelski JS. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and Other Healthcare Professionals. Part I. J Pharm Technol 2004;20:17-27. doi: 10.1177/875512250402000106.
  5. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997 Abstract
  6. Ahr HJ, Krause HP, Siefert HM, Steinke W, Weber H. Pharmacokinetics of acarbose. Part II: Distribution to and elimination from tissues and organs following single or repeated administration of [14C]acarbose to rats and dogs. Arzneimittelforschung. 1989 Abstract
  7. Ahr HJ, Boberg M, Krause HP, Maul W, Müller FO, Ploschke HJ, Weber H, Wünsche C. Pharmacokinetics of acarbose. Part I: Absorption, concentration in plasma, metabolism and excretion after single administration of [14C]acarbose to rats, dogs and man. Arzneimittelforschung. 1989 Abstract

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